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Blood, 15 June 2005, Vol. 105, No. 12, pp. 4800-4806. Prepublished online as a Blood First Edition Paper on February 10, 2005; DOI 10.1182/blood-2004-04-1406. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-04-1406v1 105/12/4800    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bélanger, S. D. Articles by St-Pierre, Y. Search for Related Content PubMed PubMed Citation Articles by Bélanger, S. D. Articles by St-Pierre, Y. Related Collections Neoplasia Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Role of selectins in the triggering, growth, and dissemination of T-lymphoma cells: implication of L-selectin in the growth of thymic lymphoma Simon D. Bélanger, and Yves St-Pierre From the Institut National de la Recherche Scientifique (INRS)-Institut Armand-Frappier, Université du Québec, Laval, Canada. We previously showed that intercellular adhesion molecule-1 (ICAM-1) expression by the host is essential for lymphoma dissemination. Because selectins usually act in a coordinated fashion with ICAM-1 in the recruitment of circulating normal cells, we investigated their implication in lymphomagenesis and metastasis. Using selectin-deficient mice, we found that though the absence of E-, P-, or L-selectins did not affect the triggering of radiation-induced thymic lymphoma, the absence of L-selectin on lymphoma cells reduced their capacity to grow in the thymus. This defect, however, was overcome by altering the integrity of the L-selectin-mediated interactions in the thymus, as shown in L-selectin-deficient mice and by adoptive transfer experiments. We also found that lack of selectin expression by the host significantly delayed the dissemination of lymphomas to peripheral tissues. This resistance of selectin-deficient mice to lymphoma metastasis was dependent on the intrinsic properties of lymphoma cells because highly tumorigenic variants were insensitive to the absence of selectins. Observations that lymphoma cells disseminate with the same efficiency in normal and selectin-deficient mice suggest that selectins exert their influence at the posthoming stage of metastasis, as does ICAM-1. These results provide definitive evidence that selectins play a significant role at different steps of T-cell lymphoma development. (Blood. 2005;105:4800-4806) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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