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Blood, 15 June 2005, Vol. 105, No. 12, pp. 4861-4864. Prepublished online as a Blood First Edition Paper on February 15, 2005; DOI 10.1182/blood-2004-12-4608. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-12-4608v1 105/12/4861    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Viatte, L. Articles by Vaulont, S. Search for Related Content PubMed PubMed Citation Articles by Viatte, L. Articles by Vaulont, S. Related Collections Red Cells Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Brief report Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice Lydie Viatte, Jeanne-Claire Lesbordes-Brion, Dan-Qing Lou, Myriam Bennoun, Gaël Nicolas, Axel Kahn, François Canonne-Hergaux, and Sophie Vaulont From the Institut National de la Santé et de la Recherche Médicale 567, Centre National de la Recherche Scientifique, et Université René Descartes, Institut Cochin, Faculté deMédecine Cochin-Port Royal, Paris, France; and the Institut National de la Santé et de la Recherche Médicale 409, Faculté de médecine Xavier Bichat, Paris, France. Evidence is accumulating that hepcidin, a liver regulatory peptide, could be the common pathogenetic denominator of all forms of iron overload syndromes including HFE-related hemochromatosis, the most prevalent genetic disorder characterized by inappropriate iron absorption. To understand the mechanisms whereby hepcidin controls iron homeostasis in vivo, we have analyzed the level of iron-related proteins by Western blot and immunohistochemistry in hepcidin-deficient mice, a mouse model of severe hemochromatosis. These mice showed important increased levels of duodenal cytochrome b (Dcytb), divalent metal transporter 1 (DMT1), and ferroportin compared with control mice. Interestingly, the level of ferroportin was coordinately up-regulated in the duodenum, the spleen, and the liver (predominantly in the Kupffer cells). Finally, we also evidenced a decrease of ceruloplasmin in the liver of hepcidin-deficient mice. We hypothesized that the deregulation of these proteins might be central in the pathogenesis of iron overload, providing key therapeutic targets for iron disorders. (Blood. 2005;105:4861-4864) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T Chaston, B Chung, M Mascarenhas, J Marks, B Patel, S K Srai, and P Sharp Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells Gut, March 1, 2008; 57(3): 374 - 382. [Abstract] [Full Text] [PDF] U. Merle, E. Fein, S. G. Gehrke, W. Stremmel, and H. Kulaksiz The Iron Regulatory Peptide Hepcidin Is Expressed in the Heart and Regulated by Hypoxia and Inflammation Endocrinology, June 1, 2007; 148(6): 2663 - 2668. [Abstract] [Full Text] [PDF] T. Ganz Molecular Control of Iron Transport J. Am. Soc. Nephrol., February 1, 2007; 18(2): 394 - 400. [Abstract] [Full Text] [PDF] M. Constante, W. Jiang, D. Wang, V.-A. Raymond, M. Bilodeau, and M. M. Santos Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G229 - G237. [Abstract] [Full Text] [PDF] D. W. Swinkels, M. C.H. Janssen, J. Bergmans, and J. J.M. Marx Hereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches Clin. Chem., June 1, 2006; 52(6): 950 - 968. [Abstract] [Full Text] [PDF] S. Chlosta, D. S. Fishman, L. Harrington, E. E. Johnson, M. D. Knutson, M. Wessling-Resnick, and B. J. Cherayil The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica. Infect. Immun., May 1, 2006; 74(5): 3065 - 3067. [Abstract] [Full Text] [PDF] L. Viatte, G. Nicolas, D.-Q. Lou, M. Bennoun, J.-C. Lesbordes-Brion, F. Canonne-Hergaux, K. Schonig, H. Bujard, A. Kahn, N. C. Andrews, et al. Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice Blood, April 1, 2006; 107(7): 2952 - 2958. [Abstract] [Full Text] [PDF] H. Mok, A. E. Mlodnicka, M. W. Hentze, M. Muckenthaler, and A. Schumacher The Molecular Circuitry Regulating the Switch between Iron Deficiency and Overload in Mice J. Biol. Chem., March 24, 2006; 281(12): 7946 - 7951. [Abstract] [Full Text] [PDF] F. Canonne-Hergaux, A. Donovan, C. Delaby, H.-j. Wang, and P. Gros Comparative studies of duodenal and macrophage ferroportin proteins Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G156 - G163. [Abstract] [Full Text] [PDF] C. Delaby, N. Pilard, A. S. Goncalves, C. Beaumont, and F. Canonne-Hergaux Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin Blood, December 1, 2005; 106(12): 3979 - 3984. [Abstract] [Full Text] [PDF]

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