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Blood, 15 January 2005, Vol. 105, No. 2, pp. 659-669.
Prepublished online as a Blood First Edition Paper on September 16, 2004; DOI 10.1182/blood-2004-07-2958.
Previous Article | Table of Contents | Next Article 
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
Dominador J. Manalo,
Ashley Rowan,
Tera Lavoie,
Lakshmi Natarajan,
Brian D. Kelly,
Shui Q. Ye,
Joe G. N. Garcia, and
Gregg L. Semenza
From the Vascular Program, Institute for Cell Engineering; the Departments of Pediatrics, Medicine, Oncology, and Radiation Oncology; and the McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial cells, leading to angiogenesis. To determine whether HIF-1 also mediates cell-autonomous responses to hypoxia, we have compared gene expression profiles in arterial endothelial cells cultured under nonhypoxic versus hypoxic conditions and in nonhypoxic cells infected with adenovirus encoding beta-galactosidase versus a constitutively active form of HIF-1 (AdCA5). There were 245 gene probes that showed at least 1.5-fold increase in expression in response to hypoxia and in response to AdCA5; 325 gene probes showed at least 1.5-fold decrease in expression in response to hypoxia and in response to AdCA5. The largest category of genes down-regulated by both hypoxia and AdCA5 encoded proteins involved in cell growth/proliferation. Many genes up-regulated by both hypoxia and AdCA5 encoded cytokines/growth factors, receptors, and other signaling proteins. Transcription factors accounted for the largest group of HIF-1regulated genes, indicating that HIF-1 controls a network of transcriptional responses to hypoxia in endothelial cells. Infection of endothelial cells with AdCA5 under nonhypoxic conditions was sufficient to induce increased basement membrane invasion and tube formation similar to the responses induced by hypoxia, indicating that HIF-1 mediates cell-autonomous activation of endothelial cells.

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|
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|
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H. Zhang, D. Z. Qian, Y. S. Tan, K. Lee, P. Gao, Y. R. Ren, S. Rey, H. Hammers, D. Chang, R. Pili, et al.
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|
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|
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19(9):
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|
 |
|

|
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|
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[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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July 1, 2008;
32(1):
105 - 112.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
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|
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[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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149(4):
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[Abstract]
[Full Text]
[PDF]
|
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|
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|
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111(6):
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|
 |
|

|
 |

|
 |
 
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February 1, 2008;
93(2):
279 - 282.
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[Full Text]
[PDF]
|
 |
|

|
 |

|
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282(51):
37064 - 37073.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Bosch-Marce, H. Okuyama, J. B. Wesley, K. Sarkar, H. Kimura, Y. V. Liu, H. Zhang, M. Strazza, S. Rey, L. Savino, et al.
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December 7, 2007;
101(12):
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[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. H. Baek, Y. V. Liu, K. R. McDonald, J. B. Wesley, H. Zhang, and G. L. Semenza
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1{alpha} (HIF-1{alpha}) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1{alpha}
J. Biol. Chem.,
November 16, 2007;
282(46):
33358 - 33366.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. L. Semenza
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92(6):
988 - 991.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. L. Semenza
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2007(407):
cm8 - cm8.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Hoogewijs, N. B. Terwilliger, K. A. Webster, J. A. Powell-Coffman, S. Tokishita, H. Yamagata, T. Hankeln, T. Burmester, K. T. Rytkonen, M. Nikinmaa, et al.
From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia
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October 1, 2007;
47(4):
552 - 577.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Piovan, V. Tosello, S. Indraccolo, M. Masiero, L. Persano, G. Esposito, R. Zamarchi, M. Ponzoni, L. Chieco-Bianchi, R. Dalla-Favera, et al.
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67(18):
8605 - 8614.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Am J Physiol Lung Cell Mol Physiol,
September 1, 2007;
293(3):
L557 - L567.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1{alpha}
J. Biol. Chem.,
August 10, 2007;
282(32):
23572 - 23580.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Fouassier, M. Beaussier, E. Schiffer, C. Rey, V. Barbu, M. Mergey, D. Wendum, P. Callard, J.-Y. Scoazec, E. Lasnier, et al.
Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes
Am J Physiol Gastrointest Liver Physiol,
July 1, 2007;
293(1):
G25 - G35.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Caretti, S. Morel, G. Milano, M. Fantacci, P. Bianciardi, R. Ronchi, G. Vassalli, L. K. von Segesser, and M. Samaja
Heart HIF-1{alpha} and MAP Kinases During Hypoxia: Are They Associated In Vivo?
Experimental Biology and Medicine,
July 1, 2007;
232(7):
887 - 894.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Gross, G. Buchwalter, H. Dubois-Pot, E. Cler, H. Zheng, and B. Wasylyk
The Ternary Complex Factor Net Is Downregulated by Hypoxia and Regulates Hypoxia-Responsive Genes
Mol. Cell. Biol.,
June 1, 2007;
27(11):
4133 - 4141.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Makino, R. Uenishi, K. Okamoto, T. Isoe, O. Hosono, H. Tanaka, A. Kanopka, L. Poellinger, M. Haneda, and C. Morimoto
Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1): A NEGATIVE FEEDBACK REGULATORY CIRCUIT IN HIF-1-MEDIATED SIGNALING IN HYPOXIC CELLS
J. Biol. Chem.,
May 11, 2007;
282(19):
14073 - 14082.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Loffler, J. C. Morote-Garcia, S. A. Eltzschig, I. R. Coe, and H. K. Eltzschig
Physiological Roles of Vascular Nucleoside Transporters
Arterioscler. Thromb. Vasc. Biol.,
May 1, 2007;
27(5):
1004 - 1013.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. Martin-Rendon, S. J.M. Hale, D. Ryan, D. Baban, S. P. Forde, M. Roubelakis, D. Sweeney, M. Moukayed, A. L. Harris, K. Davies, et al.
Transcriptional Profiling of Human Cord Blood CD133+ and Cultured Bone Marrow Mesenchymal Stem Cells in Response to Hypoxia
Stem Cells,
April 1, 2007;
25(4):
1003 - 1012.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. R. Prabhakar, T. E. Dick, J. Nanduri, and G. K. Kumar
Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia
Exp Physiol,
January 1, 2007;
92(1):
39 - 44.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y.-J. Peng, G. Yuan, D. Ramakrishnan, S. D. Sharma, M. Bosch-Marce, G. K. Kumar, G. L. Semenza, and N. R. Prabhakar
Heterozygous HIF-1{alpha} deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
J. Physiol.,
December 1, 2006;
577(2):
705 - 716.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. L. Semenza
Baffled by Bafilomycin: An Anticancer Agent That Induces Hypoxia-Inducible Factor-1{alpha} Expression
Mol. Pharmacol.,
December 1, 2006;
70(6):
1841 - 1843.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Fantacci, P. Bianciardi, A. Caretti, T. R. Coleman, A. Cerami, M. Brines, and M. Samaja
Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
PNAS,
November 14, 2006;
103(46):
17531 - 17536.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Q. Ke and M. Costa
Hypoxia-Inducible Factor-1 (HIF-1)
Mol. Pharmacol.,
November 1, 2006;
70(5):
1469 - 1480.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Kieda, R. Greferath, C. Crola Da Silva, K. C. Fylaktakidou, J.-M. Lehn, and C. Nicolau
Suppression of hypoxia-induced HIF-1{alpha} and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes
PNAS,
October 17, 2006;
103(42):
15576 - 15581.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. M. Asikainen, N. S. Waleh, B. K. Schneider, R. I. Clyman, and C. W. White
Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo
Am J Physiol Lung Cell Mol Physiol,
October 1, 2006;
291(4):
L588 - L595.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Yoon, Y. D. Pastore, V. Divoky, E. Liu, A. E. Mlodnicka, K. Rainey, P. Ponka, G. L. Semenza, A. Schumacher, and J. T. Prchal
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
J. Biol. Chem.,
September 1, 2006;
281(35):
25703 - 25711.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Fandrey, T. A. Gorr, and M. Gassmann
Regulating cellular oxygen sensing by hydroxylation
Cardiovasc Res,
September 1, 2006;
71(4):
642 - 651.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. M. Asikainen, L.-Y. Chang, J. J. Coalson, B. K. Schneider, N. S. Waleh, M. Ikegami, J. M. Shannon, V. T. Winter, P. Grubb, R. I. Clyman, et al.
Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity
FASEB J,
August 1, 2006;
20(10):
1698 - 1700.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. C. Ibla, J. Khoury, T. Kong, A. Robinson, and S. P. Colgan
Transcriptional repression of Na-K-2Cl cotransporter NKCC1 by hypoxia-inducible factor-1
Am J Physiol Cell Physiol,
August 1, 2006;
291(2):
C282 - C289.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Zampino, M. Yuzhakova, J. Hansen, R. D. McKinney, P. H. Goldspink, D. L. Geenen, and P. M. Buttrick
Sex-related dimorphic response of HIF-1{alpha} expression in myocardial ischemia
Am J Physiol Heart Circ Physiol,
August 1, 2006;
291(2):
H957 - H964.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Acker, J. Fandrey, and H. Acker
The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases
Cardiovasc Res,
July 15, 2006;
71(2):
195 - 207.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Wang, L. Weigand, W. Lu, J.T. Sylvester, G. L. Semenza, and L. A. Shimoda
Hypoxia Inducible Factor 1 Mediates Hypoxia-Induced TRPC Expression and Elevated Intracellular Ca2+ in Pulmonary Arterial Smooth Muscle Cells
Circ. Res.,
June 23, 2006;
98(12):
1528 - 1537.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Okuyama, B. Krishnamachary, Y. F. Zhou, H. Nagasawa, M. Bosch-Marce, and G. L. Semenza
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
J. Biol. Chem.,
June 2, 2006;
281(22):
15554 - 15563.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Luo, C. Jiang, A. J. Belanger, G. Y. Akita, S. C. Wadsworth, R. J. Gregory, and K. A. Vincent
A Constitutively Active Hypoxia-Inducible Factor-1{alpha}/VP16 Hybrid Factor Activates Expression of the Human B-Type Natriuretic Peptide Gene
Mol. Pharmacol.,
June 1, 2006;
69(6):
1953 - 1962.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Umeda, S. Kachi, H. Akiyama, G. Zahn, D. Vossmeyer, R. Stragies, and P. A. Campochiaro
Suppression and Regression of Choroidal Neovascularization by Systemic Administration of an {alpha}5beta1 Integrin Antagonist
Mol. Pharmacol.,
June 1, 2006;
69(6):
1820 - 1828.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. M. Mense, A. Sengupta, M. Zhou, C. Lan, G. Bentsman, D. J. Volsky, and L. Zhang
Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes
Physiol Genomics,
May 16, 2006;
25(3):
435 - 449.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Liu, S. Ramachandran, M. Ali Seyed, C. D. Scharer, N. Laycock, W. B. Dalton, H. Williams, S. Karanam, M. W. Datta, D. L. Jaye, et al.
Sex-determining region y box 4 is a transforming oncogene in human prostate cancer cells.
Cancer Res.,
April 15, 2006;
66(8):
4011 - 4019.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Hodge, E. Coghill, J. Keys, T. Maguire, B. Hartmann, A. McDowall, M. Weiss, S. Grimmond, and A. Perkins
A global role for EKLF in definitive and primitive erythropoiesis
Blood,
April 15, 2006;
107(8):
3359 - 3370.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Quintero, S. L. Colombo, A. Godfrey, and S. Moncada
Mitochondria as signaling organelles in the vascular endothelium
PNAS,
April 4, 2006;
103(14):
5379 - 5384.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Calvani, A. Rapisarda, B. Uranchimeg, R. H. Shoemaker, and G. Melillo
Hypoxic induction of an HIF-1{alpha}-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
Blood,
April 1, 2006;
107(7):
2705 - 2712.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Jokilehto, K. Rantanen, M. Luukkaa, P. Heikkinen, R. Grenman, H. Minn, P. Kronqvist, and P. M. Jaakkola
Overexpression and Nuclear Translocation of Hypoxia-Inducible Factor Prolyl Hydroxylase PHD2 in Head and Neck Squamous Cell Carcinoma Is Associated with Tumor Aggressiveness
Clin. Cancer Res.,
February 15, 2006;
12(4):
1080 - 1087.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. L. Semenza
EC does it with HIF
Blood,
January 15, 2006;
107(2):
419 - 420.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. H. Licht, F. Muller-Holtkamp, I. Flamme, and G. Breier
Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development
Blood,
January 15, 2006;
107(2):
584 - 590.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
I. Csiki, K. Yanagisawa, N. Haruki, S. Nadaf, J. D. Morrow, D. H. Johnson, and D. P. Carbone
Thioredoxin-1 Modulates Transcription of Cyclooxygenase-2 via Hypoxia-Inducible Factor-1{alpha} in Non-Small Cell Lung Cancer
Cancer Res.,
January 1, 2006;
66(1):
143 - 150.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. S. Bindra, S. L. Gibson, A. Meng, U. Westermark, M. Jasin, A. J. Pierce, R. G. Bristow, M. K. Classon, and P. M. Glazer
Hypoxia-Induced Down-regulation of BRCA1 Expression by E2Fs
Cancer Res.,
December 15, 2005;
65(24):
11597 - 11604.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Kido, L. Du, C. C. Sullivan, X. Li, R. Deutsch, S. W. Jamieson, and P. A. Thistlethwaite
Hypoxia-Inducible Factor 1-Alpha Reduces Infarction and Attenuates Progression of Cardiac Dysfunction After Myocardial Infarction in the Mouse
J. Am. Coll. Cardiol.,
December 6, 2005;
46(11):
2116 - 2124.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. K. Eltzschig, P. Abdulla, E. Hoffman, K. E. Hamilton, D. Daniels, C. Schonfeld, M. Loffler, G. Reyes, M. Duszenko, J. Karhausen, et al.
HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia
J. Exp. Med.,
December 5, 2005;
202(11):
1493 - 1505.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
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T.-C. Chang, C.-J. Huang, K. Tam, S.-F. Chen, K. T. Tan, M.-S. Tsai, T.-N. Lin, and S.-K. Shyue
Stabilization of Hypoxia-inducible Factor-1{alpha} by Prostacyclin under Prolonged Hypoxia via Reducing Reactive Oxygen Species Level in Endothelial Cells
J. Biol. Chem.,
November 4, 2005;
280(44):
36567 - 36574.
[Abstract]
[Full Text]
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H. Y. Yeung, K. P. Lai, H. Y. Chan, N. K. Mak, G. F. Wagner, and C. K. C. Wong
Hypoxia-Inducible Factor-1-Mediated Activation of Stanniocalcin-1 in Human Cancer Cells
Endocrinology,
November 1, 2005;
146(11):
4951 - 4960.
[Abstract]
[Full Text]
[PDF]
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K. R. Stenmark and V. Balasubramaniam
Angiogenic Therapy for Bronchopulmonary Dysplasia: Rationale and Promise
Circulation,
October 18, 2005;
112(16):
2383 - 2385.
[Full Text]
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T. H. Patel, H. Kimura, C. R. Weiss, G. L. Semenza, and L. V. Hofmann
Constitutively active HIF-1{alpha} improves perfusion and arterial remodeling in an endovascular model of limb ischemia
Cardiovasc Res,
October 1, 2005;
68(1):
144 - 154.
[Abstract]
[Full Text]
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R. Bilton, N. Mazure, E. Trottier, M. Hattab, M.-A. Dery, D. E. Richard, J. Pouyssegur, and M. C. Brahimi-Horn
Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1{alpha} and Is Not Induced by Hypoxia or HIF
J. Biol. Chem.,
September 2, 2005;
280(35):
31132 - 31140.
[Abstract]
[Full Text]
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G. L. Semenza
Pulmonary Vascular Responses to Chronic Hypoxia Mediated by Hypoxia-inducible Factor 1
Proceedings of the ATS,
April 1, 2005;
2(1):
68 - 70.
[Abstract]
[Full Text]
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