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Blood, 15 January 2005, Vol. 105, No. 2, pp. 697-702. Prepublished online as a Blood First Edition Paper on September 7, 2004; DOI 10.1182/blood-2004-03-1059. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-03-1059v1 105/2/697    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Feau, S. Articles by Ricciardi-Castagnoli, P. Search for Related Content PubMed PubMed Citation Articles by Feau, S. Articles by Ricciardi-Castagnoli, P. Related Collections Immunobiology Immunotherapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice Sonia Feau, Valeria Facchinetti, Francesca Granucci, Stefania Citterio, David Jarrossay, Samantha Seresini, Maria Pia Protti, Antonio Lanzavecchia, and Paola Ricciardi-Castagnoli From the Department of Biotechnology and Bioscience, University of MilanoBicocca, Milan; the Laboratory of Tumor Immunology and the Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H. San Raffaele, Milan, Italy; and the Institute for Research in Biomedicine, Bellinzona, Switzerland. Dendritic cells (DCs) are involved in the initiation and regulation of innate and adaptive immune responses. Several molecular mechanisms regulate these diverse DC functions, and we have previously reported that mouse dendritic cells (mDCs) can produce interleukin-2 (IL-2) in vitro and in vivo, in response to microbial activation and T-cell-mediated stimuli. This property is shared by different DC subtypes, including Langerhans cells. Here we show that, on appropriate stimulation, human DCs, both plasmacytoid and myeloid subtypes, also express IL-2. Interestingly, the production of IL-2 by myeloid DCs is induced by T-cell-mediated stimuli and depends on the presence of IL-15. The key role of this cytokine in regulating IL-2 production was also confirmed in the mouse system. In particular, we could show that DCs from IL-15-deficient mice were strongly impaired in the ability to produce IL-2 after interactions with different microbial stimuli. Our results indicate that DC-produced IL-2 is tightly coregulated with the expression of IL-15. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. Lapaque, T. Walzer, S. Meresse, E. Vivier, and J. Trowsdale Interactions between Human NK Cells and Macrophages in Response to Salmonella Infection J. Immunol., April 1, 2009; 182(7): 4339 - 4348. [Abstract] [Full Text] [PDF] R. Ing and M. M. Stevenson Dendritic Cell and NK Cell Reciprocal Cross Talk Promotes Gamma Interferon-Dependent Immunity to Blood-Stage Plasmodium chabaudi AS Infection in Mice Infect. Immun., February 1, 2009; 77(2): 770 - 782. [Abstract] [Full Text] [PDF] Z. Ye, C. M. L. Lee, G. W. Sun, and Y.-H. Gan Burkholderia pseudomallei Infection of T Cells Leads to T-Cell Costimulation Partially Provided by Flagellin Infect. Immun., June 1, 2008; 76(6): 2541 - 2550. [Abstract] [Full Text] [PDF] N. Regamey, C. Obregon, S. Ferrari-Lacraz, C. van Leer, M. Chanson, L. P. Nicod, and T. Geiser Airway Epithelial IL-15 Transforms Monocytes into Dendritic Cells Am. J. Respir. Cell Mol. Biol., July 1, 2007; 37(1): 75 - 84. [Abstract] [Full Text] [PDF] R. M. Prins, D. D. Vo, H. Khan-Farooqi, M.-Y. Yang, H. Soto, J. S. Economou, L. M. Liau, and A. Ribas NK and CD4 Cells Collaborate to Protect against Melanoma Tumor Formation in the Brain J. Immunol., December 15, 2006; 177(12): 8448 - 8455. [Abstract] [Full Text] [PDF] M. D. Chiesa, C. Romagnani, A. Thiel, L. Moretta, and A. Moretta Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses Blood, December 1, 2006; 108(12): 3851 - 3858. [Abstract] [Full Text] [PDF] N. Sanarico, A. Ciaramella, A. Sacchi, D. Bernasconi, P. Bossu, F. Mariani, V. Colizzi, and S. Vendetti Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response J. Leukoc. Biol., September 1, 2006; 80(3): 555 - 562. [Abstract] [Full Text] [PDF] I. Fricke, D. Mitchell, J. Mittelstadt, N. Lehan, H. Heine, T. Goldmann, A. Bohle, and S. Brandau Mycobacteria Induce IFN-{gamma} Production in Human Dendritic Cells via Triggering of TLR2 J. Immunol., May 1, 2006; 176(9): 5173 - 5182. [Abstract] [Full Text] [PDF]

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