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Blood, 15 January 2005, Vol. 105, No. 2, pp. 855-861. Prepublished online as a Blood First Edition Paper on July 15, 2004; DOI 10.1182/blood-2004-01-0177. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-01-0177v1 105/2/855    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by St. Pierre, T. G. Articles by Lindeman, R. Search for Related Content PubMed PubMed Citation Articles by St. Pierre, T. G. Articles by Lindeman, R. Related Collections Red Cells Transfusion Medicine Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSFUSION MEDICINE Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance Timothy G. St. Pierre, Paul R. Clark, Wanida Chua-anusorn, Adam J. Fleming, Gary P. Jeffrey, John K. Olynyk, Pensri Pootrakul, Erin Robins, and Robert Lindeman From the School of Physics and School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia; Thalassemia Research Center, Mahidol University, Bangkok, Thailand; SKG Radiology, St John of God Hospital, Perth, Australia; and Department of Haematology, Prince of Wales Hospital, Sydney, Australia. Measurement of liver iron concentration (LIC) is necessary for a range of iron-loading disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, aplastic anemia, and myelodysplasia. Currently, chemical analysis of needle biopsy specimens is the most common accepted method of measurement. This study presents a readily available noninvasive method of measuring and imaging LICs in vivo using clinical 1.5-T magnetic resonance imaging units. Mean liver proton transverse relaxation rates (R2) were measured for 105 humans. A value for the LIC for each subject was obtained by chemical assay of a needle biopsy specimen. High degrees of sensitivity and specificity of R2 to biopsy LICs were found at the clinically significant LIC thresholds of 1.8, 3.2, 7.0, and 15.0 mg Fe/g dry tissue. A calibration curve relating liver R2 to LIC has been deduced from the data covering the range of LICs from 0.3 to 42.7 mg Fe/g dry tissue. Proton transverse relaxation rates in aqueous paramagnetic solutions were also measured on each magnetic resonance imaging unit to ensure instrument-independent results. Measurements of proton transverse relaxivity of aqueous MnCl2 phantoms on 13 different magnetic resonance imaging units using the method yielded a coefficient of variation of 2.1%. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Liver iron measurement by MRI John B. Porter Blood 2005 105: 437-438. [Full Text] [PDF] This article has been cited by other articles: M. A. Melis, M. Cau, R. Congiu, G. Sole, S. Barella, A. Cao, M. Westerman, M. Cazzola, and R. Galanello A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron Haematologica, October 1, 2008; 93(10): 1473 - 1479. [Abstract] [Full Text] [PDF] A. Taher, F. El Rassi, H. Isma'eel, S. 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Coates MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients Blood, August 15, 2005; 106(4): 1460 - 1465. [Abstract] [Full Text] [PDF] J. C. Wood, M. Otto-Duessel, M. Aguilar, H. Nick, M. D. Nelson, T. D. Coates, H. Pollack, and R. Moats Cardiac Iron Determines Cardiac T2*, T2, and T1 in the Gerbil Model of Iron Cardiomyopathy Circulation, July 26, 2005; 112(4): 535 - 543. [Abstract] [Full Text] [PDF]

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