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Blood, 15 January 2005, Vol. 105, No. 2, pp. 862-864. Prepublished online as a Blood First Edition Paper on September 14, 2004; DOI 10.1182/blood-2004-05-1841. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-05-1841v1 105/2/862    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sensebé, L. Articles by Senecal, D. Search for Related Content PubMed PubMed Citation Articles by Sensebé, L. Articles by Senecal, D. Related Collections Hemostasis, Thrombosis, and Vascular Biology Transfusion Medicine Brief Reports Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSFUSION MEDICINE Brief report The efficiency of transfusing high doses of platelets in hematologic patients with thrombocytopenia: results of a prospective, randomized, open, blinded end point (PROBE) study Luc Sensebé, Bruno Giraudeau, Laurent Bardiaux, Eric Deconinck, Aline Schmidt, Marie-Laure Bidet, Catherine LeNiger, Elisabeth Hardy, Catherine Babault, and Delphine Senecal From the EFS Centre-Atlantique, Tours, France; INSERM CIC202, Tours, France; Etablissement Français du Sang (EFS) Bourgogne France-Comté, Besançon, France; Hematology Department, CHU Minjoz, Besançon, France; Hematology Department CHU, Angers, France; EFS Pays de Loire, Angers, France; Hematology Department CHU Morvan, Brest, France; EFS Bretagne, Brest, France; and Hematology Department CHU Bretonneau, Tours, France. We performed a prospective, randomized, open, blinded end point (PROBE) study to assess the efficiency of transfusing high doses of platelets in patients with thrombocytopenia, either acute leukemia (AL) or those undergoing autologous hematopoietic stem cell transplantation (AT). Patients were randomly assigned to receive transfusions with a target dose of 0.5 x 1011/10 kg (arm A) or 1 x 1011/10 kg (arm B). A total of 101 patients were included, of whom 96 were given at least one transfusion. The median time between the first transfusion and when the platelet count reached at least 20 x 109/L increased from 63 hours to 95 hours in the arm B group (P = .001), and the median number of transfusions was lower in this group (2; P = .037). The total number of transfused platelets did not differ between groups (14.9 x 1011 for arm A versus 18.5 x 1011 for arm B; P = .156). In such patients, a prophylactic strategy of high doses of platelets could improve platelet transfusion efficiency. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: The more the better? Andreas Greinacher Blood 2005 105: 442. [Full Text] [PDF]

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