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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1029-1035. Prepublished online as a Blood First Edition Paper on September 21, 2004; DOI 10.1182/blood-2004-03-1126. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-03-1126v1 105/3/1029    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lozier, J. N. Articles by Zhang, P. Search for Related Content PubMed PubMed Citation Articles by Lozier, J. N. Articles by Zhang, P. Related Collections Hemostasis, Thrombosis, and Vascular Biology Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Mapping of genes that control the antibody response to human factor IX in mice Jay N. Lozier, Nahid Tayebi, and Pei Zhang From the Food and Drug Administration Center for Biologics Evaluation and Research, Bethesda, MD. We tested the hypothesis that the antibody response to human factor IX in mice is controlled by genetic factors, especially histocompatibility antigens. Seven inbred mouse strains were immunized against human factor IX by adenoviral gene transfer or serial injections of human factor IX protein. A/J mice had the highest antibody response and 2 C57 mouse strains had the lowest response. We used the adenovirus vector to immunize 26 recombinant inbred mouse strains (AXB and BXA) derived from A/J and C57BL/6J mice and observed highly significant linkage (logarithmic odds [LOD] scores 4.8) for the polymorphic D17Mit62 marker that is 1 centimorgan (300 000 base pair [bp]) from the mouse major histocompatibility complex (MHC) locus (H-2). Experiments in mice with chimeric MHC genes indicated that class IaK or class II H-2 (or both) genes were critical, but other genes contributed to the antibody response. Polymorphic markers from chromosomes 1 and 10 that are near important immunoregulatory genes such as interleukin 10 and the interferon- gene show suggestive linkage (LOD scores of 2.3-2.6) to the factor IX antibody response. This study confirms the hypothesis that H-2 (and other) genes control factor IX antibody development in mice and suggests their potential importance for factor IX antibody development in humans with hemophilia B. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. Zhang, M.-y. W. Yu, R. Venable, H. J. Alter, and J. W.-K. Shih Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees PNAS, June 13, 2006; 103(24): 9214 - 9219. [Abstract] [Full Text] [PDF] J. Astermark, J. Oldenburg, A. Pavlova, E. Berntorp, A.-K. Lefvert, and for the MIBS Study Group Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A Blood, April 15, 2006; 107(8): 3167 - 3172. [Abstract] [Full Text] [PDF] J. N. Lozier and P. Zhang Mapping of Genes That Control the Antibody Response to Human FVIII in Mice. Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 1888 - 1888. [Abstract]

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