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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1170-1178. Prepublished online as a Blood First Edition Paper on September 30, 2004; DOI 10.1182/blood-2004-06-2336. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-06-2336v1 105/3/1170    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kim, A. Y. Articles by Walker, B. D. Search for Related Content PubMed PubMed Citation Articles by Kim, A. Y. Articles by Walker, B. D. Related Collections Immunobiology Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY The magnitude and breadth of hepatitis C virus–specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1 Arthur Y. Kim, Georg M. Lauer, Kei Ouchi, Marylyn M. Addo, Michaela Lucas, Julian Schulze zur Wiesch, Joerg Timm, Melinda Boczanowski, Jared E. Duncan, Alysse G. Wurcel, Deborah Casson, Raymond T. Chung, Rika Draenert, Paul Klenerman, and Bruce D. Walker From the Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA; the Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, Oxford, United Kingdom; the Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA; the Lemuel Shattuck Hospital, Jamaica Plain, MA; and the Howard Hughes Medical Institute, Chevy Chase, MD. CD8+ T-cell responses are an essential antiviral host defense in persistent viral infections, and their sustained effectiveness is thought to be critically dependent on CD4+ T-helper cells. To determine the relationship between HIV-1–induced CD4+ T-cell depletion and hepatitis C virus (HCV)–specific CD8+ T-cell responses during viral persistence, we studied 103 persons positive for HCV, 74 coinfected with HIV-1. CD8+ T-cell responses to the entire HCV polyprotein were determined by using an interferon- enzyme-linked immunospot (ELISpot) assay. Although HIV-1 infection by itself was not associated with a diminished HCV-specific response, HIV-1–associated CD4+ depletion was associated with significantly lower HCV-specific CD8+ T cells (R = 0.48, P < .0001). In contrast, declining CD4+ counts over the same range were not associated with diminished Epstein-Barr virus (EBV)– (R = 0.19, P = .31) or HIV-1–specific (R = –0.13, P = .60) CD8+ T-cell responses in persons infected with all viruses. These data indicate that frequencies of circulating HCV-specific CD8+ T-cell responses are sensitive to absolute CD4+ T-cell counts and provide a possible explanation for the accelerated HCV disease course in persons coinfected with HIV-1 and HCV. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C M Wilcox and M S Saag Gastrointestinal complications of HIV infection: changing priorities in the HAART era Gut, June 1, 2008; 57(6): 861 - 870. [Abstract] [Full Text] [PDF] V. Kasprowicz, J. Schulze zur Wiesch, T. Kuntzen, B. E. Nolan, S. Longworth, A. Berical, J. Blum, C. McMahon, L. L. Reyor, N. Elias, et al. High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome J. Virol., March 15, 2008; 82(6): 3154 - 3160. [Abstract] [Full Text] [PDF] D. Yerly, D. Heckerman, T. M. Allen, J. V. Chisholm III, K. Faircloth, C. H. Linde, N. Frahm, J. Timm, W. J. Pichler, A. Cerny, et al. Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus Clearance J. Virol., March 15, 2008; 82(6): 3147 - 3153. [Abstract] [Full Text] [PDF] S. Gaudieri, A. Rauch, L. P. Park, E. Freitas, S. Herrmann, G. 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