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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1204-1213.
Prepublished online as a Blood First Edition Paper on October 7, 2004; DOI 10.1182/blood-2004-03-1222.
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NEOPLASIA
Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia
Hidenori Sasaki,
Ichiro Nishikata,
Toshiyuki Shiraga,
Ena Akamatsu,
Takeshi Fukami,
Tomonori Hidaka,
Yoko Kubuki,
Akihiko Okayama,
Kenji Hamada,
Hisafumi Okabe,
Yoshinori Murakami,
Hirohito Tsubouchi, and
Kazuhiro Morishita
From the Department of Biochemistry, the Second Department of Internal Medicine, and the Department of Laboratory Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan; the Miyazaki Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan Science and Technology Agency (JST), Tokyo, Japan; the Fourth Department of Pharmaceutical Research, Chugai Pharmaceutical Co, Kanagawa, Japan; and the Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, Tokyo, Japan.
Adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type 1 (HTLV-1) infection, occurs in 2% to 4% of the HTLV-1 carriers with a long latent period, suggesting that additional alterations participate in the development of ATL. To characterize and identify novel markers of ATL, we examined the expression profiles of more than 12 000 genes in 8 cases of acute-type ATL using microarray. One hundred ninety-two genes containing interleukin 2 (IL-2) receptor  were up-regulated more than 2-fold compared with CD4+ and CD4+CD45RO+ T cells, and tumor suppressor in lung cancer 1 (TSLC1), caveolin 1, and prostaglandin D2 synthase showed increased expression of more than 30-fold. TSLC1 is a cell adhesion molecule originally identified as a tumor suppressor in the lung but lacks its expression in normal or activated T cells. We confirmed ectopic expression of the TSLC1 in all acute-type ATL cells and in 7 of 10 ATL- or HTLV-1–infected T-cell lines. Introduction of TSLC1 into a human ATL cell line ED enhanced both self-aggregation and adhesion ability to vascular endothelial cells. These results suggested that the ectopic expression of TSLC1 could provide a novel marker for acute-type ATL and may participate in tissue invasion, a characteristic feature of the malignant ATL cells.
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