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Blood, 1 February 2005, Vol. 105, No. 3, pp. 1343-1347. Prepublished online as a Blood First Edition Paper on October 5, 2004; DOI 10.1182/blood-2004-07-2717. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-07-2717v1 105/3/1343    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Barker, J. N. Articles by Wagner, J. E. Search for Related Content PubMed PubMed Citation Articles by Barker, J. N. Articles by Wagner, J. E. Related Collections Immunobiology Neoplasia Transplantation Free Research Articles Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy Juliet N. Barker, Daniel J. Weisdorf, Todd E. DeFor, Bruce R. Blazar, Philip B. McGlave, Jeffrey S. Miller, Catherine M. Verfaillie, and John E. Wagner From the Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis. Limited umbilical cord blood (UCB) cell dose compromises the outcome of adult UCB transplantation. Therefore, to augment graft cell dose, we evaluated the safety of the combined transplantation of 2 partially human leukocyte antigen (HLA)–matched UCB units. Twenty-three patients with high-risk hematologic malignancy (median age, 24 years; range, 13-53 years) received 2 UCB units (median infused dose, 3.5 x 107 nucleated cell [NC]/kg; range, 1.1-6.3 x 107 NC/kg) after myeloablative conditioning. All evaluable patients (n = 21) engrafted at a median of 23 days (range, 15-41 days). At day 21, engraftment was derived from both donors in 24% of patients and a single donor in 76% of patients, with 1 unit predominating in all patients by day 100. Although neither nucleated or CD34+ cell doses nor HLA-match predicted which unit would predominate, the predominating unit had a significantly higher CD3+ dose (P < .01). Incidences of grades II-IV and III-IV acute GVHD were 65% (95% confidence interval [CI], 42%-88%) and 13% (95% CI, 0%-26%), respectively. Disease-free survival was 57% (95% CI, 35%-79%) at 1 year, with 72% (95% CI, 49%-95%) of patients alive if they received transplants while in remission. Therefore, transplantation of 2 partially HLA-matched UCB units is safe, and may overcome the cell-dose barrier that limits the use of UCB in many adults and adolescents. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Transplantation of 2 UCB units in adults Mary J. Laughlin Blood 2005 105: 915-916. [Full Text] [PDF] This article has been cited by other articles: A. Y. H. Leung and Y.-L. Kwong Haematopoietic stem cell transplantation: current concepts and novel therapeutic strategies Br. Med. Bull., November 8, 2009; (2009) ldp040v1. [Abstract] [Full Text] [PDF] M. Delaney Are 2 cords better than 1? Blood, November 5, 2009; 114(19): 3980 - 3981. [Full Text] [PDF] M. R. Verneris, C. G. Brunstein, J. Barker, M. L. MacMillan, T. DeFor, D. H. McKenna, M. J. Burke, B. R. Blazar, J. S. Miller, P. B. McGlave, et al. 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