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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1408-1416. Prepublished online as a Blood First Edition Paper on October 14, 2004; DOI 10.1182/blood-2004-06-2385. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-06-2385v1 105/4/1408    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Oh, H. Articles by Barrett, A. J. Search for Related Content PubMed PubMed Citation Articles by Oh, H. Articles by Barrett, A. J. Related Collections Transplantation Clinical Trials and Observations Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations Hakumei Oh, Fausto R. Loberiza, Jr, Mei-jie Zhang, Olle Ringdén, Hideki Akiyama, Takayoshi Asai, Shuichi Miyawaki, Shinichiro Okamoto, Mary M. Horowitz, Joseph H. Antin, Asad Bashey, Jennifer M. Bird, Matthew H. Carabasi, Joseph W. Fay, Robert Peter Gale, Roger H. Giller, John M. Goldman, Gregory A. Hale, Richard E. Harris, Jean Henslee-Downey, Hans-Jochem Kolb, Mark R. Litzow, Philip L. McCarthy, Steven M. Neudorf, Derek S. Serna, Gerard Socié, Pierre Tiberghien, and A. John Barrett From the GVHD/Immune Reconstitution Working Committee of the International Bone Marrow Transplant Registry (IBMTR), Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI; INOUE Memorial Hospital, Chiba, Japan; Huddinge University Hospital, Sweden; Japan Adult Leukemia Study Group, Tokyo Metropolitan Komagome Hospital, Japan; Chiba University Hospital, Chuo-Ku, Japan; Saiseikai Maebashi Hospital, Maebashi, Japan; Keio University School of Medicine, Tokyo, Japan; Dana-Farber Cancer Institute, Boston, MA; University of California at San Diego, La Jolla; Southmead Hospital, Clifton, Bristol, United Kingdom; University of Southern California/Norris Cancer Center, Los Angeles; Baylor University Medical Center, Dallas, TX; Center for Advanced Studies in Leukemia, Los Angeles, CA; The Children's Hospital, Denver, CO; Hammersmith Hospital, London, United Kingdom; St Jude Children's Research Hospital, Memphis, TN; Children's Hospital Medical Center, Cincinnati, OH; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD; University of Munich, Germany; Mayo Clinic, Rochester, MN; Roswell Park Cancer Institute, Buffalo, NY; Children's Hospital of Orange County, Orange, CA; Hospital Saint Louis, Paris, Cedex, France; and Inserm U645 Etablissement Francais du Sang, Besancon, France. The association of ethnicity with the incidence of graft-versus-host disease (GVHD) and other clinical outcomes after transplantation is controversial. We compared the results of HLA-identical sibling bone marrow transplantations for leukemia, performed between 1990 and 1999, among different ethnic populations, including 562 Japanese, 829 white Americans, 71 African Americans, 195 Scandinavians, and 95 Irish. Results for adults and children were analyzed separately. Multivariate analyses of adult patients showed that white Americans, African Americans, and Irish cohorts were at significantly higher risk for acute GVHD than Japanese or Scandinavian cohorts (relative risk [RR] = 1.77, P < .001; RR = 1.84, P < .006; RR = 2.22, P < .001, respectively). White Americans, African Americans, and Irish, but not Scandinavians, were at significantly higher risk for early (within 3 months of transplantation) transplant-related mortality (TRM) compared with Japanese (RR = 2.99, P < .001; RR = 5.88, P < .001; RR = 2.66, P < .009, respectively). No differences in the risk for chronic GVHD, relapse, and overall survival were noted. In the pediatric cohort (limited to Japanese and white Americans), white Americans were at significantly higher risk for acute (RR = 1.93; P = .04) and chronic (RR = 3.16; P = .002) GVHD. No differences in other clinical outcomes were noted. Our findings suggest that ethnicity may influence the risk for GVHD, though overall survival rates after transplantation remain similar. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Major minors only? Nelson J. Chao Blood 2005 105: 1377-1378. [Full Text] [PDF] This article has been cited by other articles: X. Y. Han Epidemiologic Analysis of Reactivated Cytomegalovirus Antigenemia in Patients with Cancer J. Clin. Microbiol., April 1, 2007; 45(4): 1126 - 1132. [Abstract] [Full Text] [PDF] S. Takahashi, J. Ooi, A. Tomonari, T. Konuma, N. Tsukada, M. Oiwa-Monna, K. Fukuno, M. Uchiyama, K. Takasugi, T. Iseki, et al. Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen Blood, February 1, 2007; 109(3): 1322 - 1330. [Abstract] [Full Text] [PDF] M.-T. Lin, B. Storer, P. J. Martin, L.-H. Tseng, B. Grogan, P.-J. Chen, L. P. Zhao, and J. A. Hansen Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor {beta} genotype of donor Blood, December 1, 2005; 106(12): 3995 - 4001. [Abstract] [Full Text] [PDF]

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