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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1417-1423. Prepublished online as a Blood First Edition Paper on October 19, 2004; DOI 10.1182/blood-2004-08-3175. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-08-3175v1 105/4/1417    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Marcus, R. Articles by Smith, P. Search for Related Content PubMed PubMed Citation Articles by Marcus, R. Articles by Smith, P. Related Collections Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma Robert Marcus, Kevin Imrie, Andrew Belch, David Cunningham, Eduardo Flores, John Catalano, Philippe Solal-Celigny, Fritz Offner, Jan Walewski, Joäo Raposo, Andrew Jack, and Paul Smith From Addenbrooke's Hospital, Cambridge, United Kingdom; Toronto-Sunnybrook Regional Cancer Center, Toronto, ON, Canada; Cross Cancer Institute, Edmonton, AB, Canada; Royal Marsden Hospital, Surrey, United Kingdom; Hospital Gregorio Marañón, Madrid, Spain; Monash Medical Centre, Clayton, Australia; Clinique Victor Hugo, Le Mans, France; Dienst Hematologie, UZ Gent, Belgium; M. Sklodowska-Curie Memorial Institute, Warszawa, Poland; Hospital Santa Maria, Lisboa, Portugal; Leeds General Infirmary, Leeds, United Kingdom; and Cancer Research UK and University College London (UCL) Cancer Trials Centre, London, United Kingdom. The combination of cyclophosphamide, vincristine, and prednisone (CVP) is one of several standard treatment options for advanced follicular lymphoma. This, like similar chemotherapeutic regimens, induces response rates of 60% to 80%, with a median response duration of under 2 years. Rituximab, a chimeric monoclonal antibody against CD20, is active in follicular lymphoma, both as monotherapy and in combination with chemotherapy. Previously untreated patients with stages III to IV follicular lymphoma were randomly assigned to receive either 8 cycles of CVP plus rituximab (R-CVP; n = 162) or CVP (n = 159). Overall and complete response rates were 81% and 41% in the R-CVP arm versus 57% and 10% in the CVP arm, respectively (P < .0001). At a median follow-up of 30 months, patients treated with R-CVP had a very significantly prolonged time to progression (median 32 months versus 15 months for CVP; P < .0001). Median time to treatment failure was 27 months in patients receiving R-CVP and 7 months in the CVP arm (P < .0001). Rituximab did not add significantly to the toxicity of CVP. The addition of rituximab to the CVP regimen significantly improves the clinical outcome in patients with previously untreated advanced follicular lymphoma, without increased toxicity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Rituximab and poor-risk follicular lymphoma Craig H. Moskowitz Blood 2005 105: 1380. [Full Text] [PDF] This article has been cited by other articles: N. A. Johnson and R. D. Gascoyne Gene expression signatures in follicular lymphoma: are they ready for the clinic? Haematologica, July 1, 2008; 93(7): 982 - 987. [Full Text] [PDF] C. Tarella, M. 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