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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1523-1530. Prepublished online as a Blood First Edition Paper on October 21, 2004; DOI 10.1182/blood-2004-09-3531. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-09-3531v1 105/4/1523    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lemieux, C. Articles by Sirois, M. G. Search for Related Content PubMed PubMed Citation Articles by Lemieux, C. Articles by Sirois, M. G. Related Collections Hemostasis, Thrombosis, and Vascular Biology Phagocytes Cell Adhesion and Motility Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses Caroline Lemieux, Ricardo Maliba, Judith Favier, Jean-François Théorêt, Yahye Merhi, and Martin G. Sirois From the Research Center, Montreal Heart Institute, Montreal, QC, Canada; and Department of Pharmacology, Université de Montréal, Montreal, QC, Canada. Angiopoietin-1 (Ang1) and -2 (Ang2) are endothelial growth factors that bind to the tyrosine kinase receptor Tie2 and contribute to orchestrate blood vessel formation during angiogenesis. Ang1 mediates vessel maturation and integrity by the recruitment of pericytes. In contrast, Ang2 is classically considered as a Tie2 antagonist, counteracting the stabilizing action of Ang1. Inflammation exists in a mutually dependent association with angiogenesis and we have therefore studied the capacity of angiopoietins to modulate proinflammatory activities, namely P-selectin translocation and neutrophil adhesion onto endothelial cells. We observed that both Ang1 and Ang2 increased these biologic activities. Furthermore, combination of Ang1/Ang2 induced an additive effect on neutrophil adhesion but not on P-selectin translocation. In an attempt to clarify this phenomenon, we found that angiopoietins can directly activate neutrophils through Tie2 signaling as well as modulate platelet-activating factor (PAF) synthesis and 2 integrin functional up-regulation. Together, our data demonstrate that angiopoietins could promote acute recruitment of leukocytes, which might contribute to facilitate vascular remodeling and angiogenesis. 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