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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1614-1621. Prepublished online as a Blood First Edition Paper on October 26, 2004; DOI 10.1182/blood-2004-07-2507. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-07-2507v1 105/4/1614    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Odendahl, M. Articles by Dörner, T. Search for Related Content PubMed PubMed Citation Articles by Odendahl, M. Articles by Dörner, T. Related Collections Hematopoiesis and Stem Cells Immunobiology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response Marcus Odendahl, Henrik Mei, Bimba F. Hoyer, Annett M. Jacobi, Arne Hansen, Gwendolin Muehlinghaus, Claudia Berek, Falk Hiepe, Rudi Manz, Andreas Radbruch, and Thomas Dörner From the Departments of Medicine, Rheumatology, and Clinical Immunology, and the Institute of Transfusion Medicine, Coagulation Unit, Charité, University Medicine, Humboldt University; and the German Arthritis Research Center, Berlin, Germany. Maintenance of protective humoral immunity depends on the generation and survival of antibody-secreting cells. The bone marrow provides niches for long-term survival of plasma cells generated in the course of systemic immune responses in secondary lymphoid organs. Here, we have analyzed migratory human plasma blasts and plasma cells after secondary vaccination with tetanus toxin. On days 6 and 7 after immunization, CD19+/CD27high/intracellular immunoglobulin Ghigh (IgGhigh)/HLA-DRhigh/CD38high/CD20–/CD95+ tetanus toxin–specific antibody-secreting plasma blasts were released in large numbers from the secondary lymphoid organs into the blood. These cells show chemotactic responsiveness toward ligands for CXCR3 and CXCR4, probably guiding them to the bone marrow or inflamed tissue. At the same time, a population of CD19+/CD27high/intracellular IgGhigh/HLA-DRlow/CD38+/CD20–/CD95+ cells appeared in the blood in large numbers. These cells, with the phenotype of long-lived plasma cells, secreted antibodies of unknown specificity, not tetanus toxoid. The appearance of these plasma cells in the blood indicates successful competition for survival niches in the bone marrow between newly generated plasma blasts and resident plasma cells as a fundamental mechanism for the establishment of humoral memory and its plasticity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Hansson, M. Hermansson, H. Svensson, A. Elfvin, L.-E. Hansson, E. Johnsson, A. Sjoling, and M. Quiding-Jarbrink CCL28 Is Increased in Human Helicobacter pylori-Induced Gastritis and Mediates Recruitment of Gastric Immunoglobulin A-Secreting Cells Infect. Immun., July 1, 2008; 76(7): 3304 - 3311. [Abstract] [Full Text] [PDF] A. Geffroy-Luseau, G. Jego, R. Bataille, L. Campion, and C. Pellat-Deceunynck Osteoclasts support the survival of human plasma cells in vitro Int. Immunol., June 1, 2008; 20(6): 775 - 782. [Abstract] [Full Text] [PDF] M. Mamani-Matsuda, A. Cosma, S. Weller, A. 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