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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1797-1802. Prepublished online as a Blood First Edition Paper on October 12, 2004; DOI 10.1182/blood-2004-08-3375. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-08-3375v1 105/4/1797    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rivera, S. Articles by Ganz, T. Search for Related Content PubMed PubMed Citation Articles by Rivera, S. Articles by Ganz, T. Related Collections Neoplasia Red Cells Free Research Articles Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia Seth Rivera, Lide Liu, Elizabeta Nemeth, Victoria Gabayan, Ole E. Sorensen, and Tomas Ganz From the Departments of Medicine and Pathology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA. The iron-regulatory hormone hepcidin has been proposed as the mediator of anemia of inflammation (AI). We examined the acute and chronic effects of hepcidin in the mouse. Injections of human hepcidin (50 µg/mouse), but not of its diluent, induced hypoferremia within 4 hours. To examine the chronic effects of hepcidin, we implanted either tumor xenografts engineered to overexpress human hepcidin or control tumor xenografts into nonobese diabetic-severe combined immunodeficiency (NOD-SCID) mice. Despite abundant dietary iron, mice with hepcidin-producing tumors developed more severe anemia, lower serum iron, and increased hepatic iron compared with mice with control tumors. Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes. (Blood. 2005;105:1797-1802) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Iron is still hot: hepcidin keeps it ablaze Prem Ponka Blood 2005 105: 1376-1377. [Full Text] [PDF] This article has been cited by other articles: S. Sharma, E. Nemeth, Y.-H. Chen, J. Goodnough, A. Huston, G.D. Roodman, T. Ganz, and A. Lichtenstein Involvement of Hepcidin in the Anemia of Multiple Myeloma Clin. Cancer Res., June 1, 2008; 14(11): 3262 - 3267. [Abstract] [Full Text] [PDF] A. T. Murphy, D. R. Witcher, P. Luan, and V. J. Wroblewski Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry Blood, August 1, 2007; 110(3): 1048 - 1054. [Abstract] [Full Text] [PDF] C. N. Roy, H. H. Mak, I. Akpan, G. Losyev, D. Zurakowski, and N. C. Andrews Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation Blood, May 1, 2007; 109(9): 4038 - 4044. [Abstract] [Full Text] [PDF] T. Ganz Molecular Control of Iron Transport J. Am. Soc. Nephrol., February 1, 2007; 18(2): 394 - 400. [Abstract] [Full Text] [PDF] D. W. Swinkels, M. C.H. Janssen, J. Bergmans, and J. J.M. Marx Hereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches Clin. Chem., June 1, 2006; 52(6): 950 - 968. [Abstract] [Full Text] [PDF] L. Viatte, G. Nicolas, D.-Q. Lou, M. Bennoun, J.-C. Lesbordes-Brion, F. Canonne-Hergaux, K. Schonig, H. Bujard, A. Kahn, N. C. Andrews, et al. Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice Blood, April 1, 2006; 107(7): 2952 - 2958. [Abstract] [Full Text] [PDF] T. Ganz and E. Nemeth Iron imports. IV. Hepcidin and regulation of body iron metabolism Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G199 - G203. [Abstract] [Full Text] [PDF] T. Ganz Hepcidin and Its Role in Regulating Systemic Iron Metabolism Hematology, January 1, 2006; 2006(1): 29 - 35. [Abstract] [Full Text] [PDF] E. Nemeth, G. C. Preza, C.-L. Jung, J. Kaplan, A. J. Waring, and T. Ganz The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study Blood, January 1, 2006; 107(1): 328 - 333. [Abstract] [Full Text] [PDF] D. M. Frazer and G. J. Anderson Iron Imports. I. Intestinal iron absorption and its regulation Am J Physiol Gastrointest Liver Physiol, October 1, 2005; 289(4): G631 - G635. [Abstract] [Full Text] [PDF] S. Rivera, E. Nemeth, V. Gabayan, M. A. Lopez, D. Farshidi, and T. Ganz Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs Blood, September 15, 2005; 106(6): 2196 - 2199. [Abstract] [Full Text] [PDF] A. Maccio, C. Madeddu, D. Massa, M. C. Mudu, M. R. Lusso, G. Gramignano, R. Serpe, G. B. Melis, and G. Mantovani Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia Blood, July 1, 2005; 106(1): 362 - 367. [Abstract] [Full Text] [PDF] G. Papanikolaou, M. Tzilianos, J. I. Christakis, D. Bogdanos, K. Tsimirika, J. MacFarlane, Y. P. Goldberg, N. Sakellaropoulos, T. Ganz, and E. Nemeth Hepcidin in iron overload disorders Blood, May 15, 2005; 105(10): 4103 - 4105. [Abstract] [Full Text] [PDF]

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