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Blood, 1 March 2005, Vol. 105, No. 5, pp. 1992-1999. Prepublished online as a Blood First Edition Paper on November 2, 2004; DOI 10.1182/blood-2004-07-2598. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-07-2598v1 105/5/1992    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Murga, M. Articles by Tosato, G. Search for Related Content PubMed PubMed Citation Articles by Murga, M. Articles by Tosato, G. Related Collections Hemostasis, Thrombosis, and Vascular Biology Cell Adhesion and Motility Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2 Matilde Murga, Oscar Fernandez-Capetillo, and Giovanna Tosato From the Experimental Transplantation and Immunology Branch, Center for Cancer Research, and the Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD. Neuropilin-1 (NRP-1) is a type 1 membrane protein that binds the axon guidance factors belonging to the class-3 semaforin family. In endothelial cells, NRP-1 serves as a co-receptor for vascular endothelial growth factor (VEGF) and regulates VEGF receptor 2 (VEGFR-2)–dependent angiogenesis. Although gene-targeting studies documenting embryonic lethality in NRP-1 null mice have demonstrated a critical role for NRP-1 in vascular development, the activities of NRP-1 in mature endothelial cells have been incompletely defined. Using RNA interference-mediated silencing of NRP-1 or VEGFR-2 in primary human endothelial cells, we confirm that NRP-1 modulates VEGFR-2 signaling-dependent mitogenic functions of VEGF. Importantly, we now show that NRP-1 regulates endothelial cell adhesion to extracellular matrix proteins independently of VEGFR-2. Based on its dual role as an enhancer of VEGF activity and a mediator of endothelial cell adhesiveness described here, NRP-1 emerges as a promising molecular target for the development of antiangiogenic drugs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Sakakibara, C. A. Pise-Masison, J. N. Brady, and G. 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Hong, Y.-L. Chen, Y.-Y. Wu, A. Yuan, Y.-C. Chao, Y.-C. Chung, M.-H. Wu, S.-C. Yang, S.-H. Pan, J.-Y. Shih, et al. Targeting Neuropilin 1 as an Antitumor Strategy in Lung Cancer Clin. Cancer Res., August 15, 2007; 13(16): 4759 - 4768. [Abstract] [Full Text] [PDF] O. Salvucci, M. de la Luz Sierra, J. A. Martina, P. J. McCormick, and G. Tosato EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling Blood, November 1, 2006; 108(9): 2914 - 2922. [Abstract] [Full Text] [PDF] L. Wang, D. Mukhopadhyay, and X. Xu C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis FASEB J, July 1, 2006; 20(9): 1513 - 1515. [Abstract] [Full Text] [PDF] H. Jia, A. Bagherzadeh, B. Hartzoulakis, A. Jarvis, M. Lohr, S. Shaikh, R. Aqil, L. Cheng, M. Tickner, D. Esposito, et al. Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR Signaling J. Biol. Chem., May 12, 2006; 281(19): 13493 - 13502. [Abstract] [Full Text] [PDF] L. M. Ellis The role of neuropilins in cancer Mol. Cancer Ther., May 1, 2006; 5(5): 1099 - 1107. [Abstract] [Full Text] [PDF] D. H. Damon Vascular endothelial-derived semaphorin 3 inhibits sympathetic axon growth Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1220 - H1225. [Abstract] [Full Text] [PDF] C. K. Williams, J.-L. Li, M. Murga, A. L. Harris, and G. Tosato Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function Blood, February 1, 2006; 107(3): 931 - 939. [Abstract] [Full Text] [PDF] M. J. Gray, J. S. Wey, A. Belcheva, M. F. McCarty, J. G. Trevino, D. B. Evans, L. M. Ellis, and G. E. Gallick Neuropilin-1 Suppresses Tumorigenic Properties in a Human Pancreatic Adenocarcinoma Cell Line Lacking Neuropilin-1 Coreceptors Cancer Res., May 1, 2005; 65(9): 3664 - 3670. [Abstract] [Full Text] [PDF]

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