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 Blood, 1 March 2005, Vol. 105, No. 5, pp. 2138-2140.
Prepublished online as a Blood First Edition Paper on October 19, 2004; DOI 10.1182/blood-2004-06-2375.

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NEOPLASIA
Brief report

High telomerase activity in granulocytes from clonal polycythemia vera and essential thrombocythemia

Anna Maria Ferraris, Rosa Mangerini, Natalija Pujic, Omar Racchi, Davide Rapezzi, Andrea Gallamini, Salvatore Casciaro, and Gian Franco Gaetani

From the Ematologia Oncologica, Istituto Nazionale per la Ricerca sul Cancro; the Dipartimento di Medicina Interna, University of Genova; and the Struttura Complessa di Ematologia, Azienda Ospedaliera Santa Croce e Carle, Cuneo, Italy.

Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic indicators, we analyzed telomerase activity (TA), a known marker of neoplastic proliferation, in granulocytes (PMNs) and mononuclear cells (MNCs) from 22 female patients with ET and PV. Clonality status was determined by investigation of X chromosome inactivation patterns (XCIPs). We found a statistically significant positive correlation between high TA and monoclonal pattern of XCIP. Therefore, our data suggest that the use of multiple tumor markers may contribute to a better understanding of the deregulated physiology of these disorders and provide useful prognostic factors.


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