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Blood, 15 March 2005, Vol. 105, No. 6, pp. 2294-2299. Prepublished online as a Blood First Edition Paper on November 30, 2004; DOI 10.1182/blood-2004-07-2599. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-07-2599v1 105/6/2294    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ferrucci, L. Articles by Longo, D. L. Search for Related Content PubMed PubMed Citation Articles by Ferrucci, L. Articles by Longo, D. L. Related Collections Hemostasis, Thrombosis, and Vascular Biology Immunobiology Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS The origins of age-related proinflammatory state Luigi Ferrucci, Annamaria Corsi, Fulvio Lauretani, Stefania Bandinelli, Benedetta Bartali, Dennis D. Taub, Jack M. Guralnik, and Dan L. Longo From the Intramural Research Program, National Institute on Aging, Baltimore, MD; the Laboratory of Clinical Epidemiology, Italian National Institute of Research and Care of Aging, Florence, Italy; and the Division of Nutritional Sciences, Cornell University, Ithaca, NY. We hypothesized that the rising levels of inflammatory markers with aging is explained by cardiovascular risk factors and morbidity becoming progressively more prevalent in older persons. Information on inflammatory markers, cardiovascular risk factors, and diseases was collected in 595 men and 748 women sampled from the general population (age, 20-102 years). In both men and women, older age was associated with higher levels of interleukin-6 (IL-6), IL-1 receptor antagonist (IL-1ra), IL-18, C-reactive protein (CRP), and fibrinogen, while soluble IL-6 receptor (sIL-6r) increased significantly with age only in men. Adjusting for cardiovascular risk factors and morbidity, the age regression coefficients became substantially smaller in models predicting IL-6, IL-1ra, IL-18, and fibrinogen and larger in the model predicting sIL6r. Adjustment for cardiovascular morbidity substantially reduced the effect of age on CRP in men but not in women. Findings were confirmed in a subgroup of 51 men and 45 women with low risk profile and no cardiovascular morbidity. Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Inflammation gone awry: aging or disease William B. Ershler Blood 2005 105: 2247. [Full Text] [PDF] This article has been cited by other articles: K. Thomas, S. Rafiq, T. M. Frayling, S. Ebrahim, M. Kumari, J. Gallacher, L. Ferrucci, S. Bandinelli, R. B. Wallace, D. Melzer, et al. Interleukin-18 Polymorphism and Physical Functioning in Older People: A Replication Study and Meta-Analysis J Gerontol A Biol Sci Med Sci, November 1, 2009; 64A(11): 1177 - 1182. [Abstract] [Full Text] [PDF] M. E. Starr, B. M. Evers, and H. Saito Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6 J Gerontol A Biol Sci Med Sci, July 1, 2009; 64A(7): 723 - 730. [Abstract] [Full Text] [PDF] K. A. 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