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Blood, 15 March 2005, Vol. 105, No. 6, pp. 2400-2402. Prepublished online as a Blood First Edition Paper on November 30, 2004; DOI 10.1182/blood-2004-02-0612. This Article Full Text Full Text (PDF) Supplemental Videos All Versions of this Article: 2004-02-0612v1 105/6/2400    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Galimi, F. Articles by Gage, F. H. Search for Related Content PubMed PubMed Citation Articles by Galimi, F. Articles by Gage, F. H. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Phagocytes Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report A role for bone marrow–derived cells in the vasculature of noninjured CNS Francesco Galimi, Robert G. Summers, Henriette van Praag, Inder M. Verma, and Fred H. Gage From the Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA; and the Department of Biomedical Sciences/Instituto Nazionale di Biostrutture e Biosistemi, University of Sassari Medical School, Sassari, Italy. The contribution of hematopoietic cells to the formation of blood vessels is currently the focus of intense scrutiny. Bone marrow–derived endothelial progenitor cells are thought to generate endothelial cells in many tissues, including myocardium, muscle, and certain tumors. In the central nervous system (CNS), however, the possible role of bone marrow–derived angiocompetent cells remains unclear. Here we have investigated the long-term involvement of bone marrow–derived cells in the maintenance of endothelial structures in the brain, spinal cord, and retina. Using hematopoietic chimeras stably expressing green fluorescent protein (GFP) in bone marrow–derived tissues, we found large numbers of hematopoietic cells closely associated with vessels in the CNS. None of these cells, however, showed an endothelial phenotype. They were positive for monocytic and microglial surface markers and demonstrated active phagocytosis of neighboring endothelial elements. Bone marrow–derived, vasculature-associated cells in the noninjured adult CNS are distinct from endothelial cells, but play an active role in vascular structures. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. P.W. Rouhl, R. J. van Oostenbrugge, J. Damoiseaux, J.-W. C. Tervaert, and J. Lodder Endothelial Progenitor Cell Research in Stroke: A Potential Shift in Pathophysiological and Therapeutical Concepts Stroke, July 1, 2008; 39(7): 2158 - 2165. [Abstract] [Full Text] [PDF] C Boettcher, E Ulbricht, D Helmlinger, A F Mack, A Reichenbach, P Wiedemann, H-J Wagner, M W Seeliger, A Bringmann, and J Priller Long-term engraftment of systemically transplanted, gene-modified bone marrow-derived cells in the adult mouse retina Br. J. Ophthalmol., February 1, 2008; 92(2): 272 - 275. [Abstract] [Full Text] [PDF] K. Gertz, J. Priller, G. Kronenberg, K. B. Fink, B. Winter, H. Schrock, S. Ji, M. Milosevic, C. Harms, M. Bohm, et al. Physical Activity Improves Long-Term Stroke Outcome via Endothelial Nitric Oxide Synthase-Dependent Augmentation of Neovascularization and Cerebral Blood Flow Circ. Res., November 10, 2006; 99(10): 1132 - 1140. [Abstract] [Full Text] [PDF] U. Ozerdem, K. Alitalo, P. Salven, and A. Li Contribution of Bone Marrow-Derived Pericyte Precursor Cells to Corneal Vasculogenesis Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3502 - 3506. [Abstract] [Full Text] [PDF]

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