Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 March 2005, Vol. 105, No. 6, pp. 2421-2427.
Prepublished online as a Blood First Edition Paper on September 21, 2004; DOI 10.1182/blood-2004-07-2823.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2004-07-2823v1
105/6/2421    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Piccio, L.
Right arrow Articles by Colonna, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piccio, L.
Right arrow Articles by Colonna, M.
Related Collections
Right arrow Cell Adhesion and Motility
Right arrow Signal Transduction
Right arrow Immunobiology
Right arrowRelated Article in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

IMMUNOBIOLOGY

Adhesion of human T cells to antigen-presenting cells through SIRP{beta}2-CD47 interaction costimulates T-cell proliferation

Laura Piccio, William Vermi, Kent S. Boles, Anja Fuchs, Carey A. Strader, Fabio Facchetti, Marina Cella, and Marco Colonna

From the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO; Department of Neurological Sciences, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Maggiore Policlinico, and "Dino Ferrari" Center, Milano, Italy; and Department of Pathology, University of Brescia, Brescia, Italy.

Signal-regulatory proteins (SIRPs) are transmembrane glycoproteins belonging to the immunoglobulin (Ig) superfamily that are expressed in the immune and central nervous systems. SIRP{alpha} binds CD47 and inhibits the function of macrophages, dendritic cells, and granulocytes, whereas SIRP{beta}1 is an orphan receptor that activates the same cell types. A recently identified third member of the SIRP family, SIRP{beta}2, is as yet uncharacterized in terms of expression, specificity, and function. Here, we show that SIRP{beta}2 is expressed on T cells and activated natural killer (NK) cells and, like SIRP{alpha}, binds CD47, mediating cell-cell adhesion. Consequently, engagement of SIRP{beta}2 on T cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article in Blood Online:

CD47 and SIRPs: new openings
Per-Arne Oldenborg
Blood 2005 105: 2245-2246. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 BloodHome page
M. Stefanidakis, G. Newton, W. Y. Lee, C. A. Parkos, and F. W. Luscinskas
Endothelial CD47 interaction with SIRP{gamma} is required for human T-cell transendothelial migration under shear flow conditions in vitro
Blood, August 15, 2008; 112(4): 1280 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Shi, K. Luo, D. Xia, T. Chen, G. Chen, Y. Jiang, N. Li, and X. Cao
DIgR2, dendritic cell-derived immunoglobulin receptor 2, is one representative of a family of IgSF inhibitory receptors and mediates negative regulation of dendritic cell-initiated antigen-specific T-cell responses
Blood, October 15, 2006; 108(8): 2678 - 2686.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
Sponsor: Genentech BioOncology and and Biogen Idec
Blood Online is supported in part by
Genentech BioOncology and Biogen Idec
  Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020