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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2631-2639. Prepublished online as a Blood First Edition Paper on December 7, 2004; DOI 10.1182/blood-2004-06-2480. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-06-2480v1 105/7/2631    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Taichman, R. S. Search for Related Content PubMed PubMed Citation Articles by Taichman, R. S. Related Collections Hematopoiesis and Stem Cells Apoptosis Cell Adhesion and Motility Signal Transduction Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche Russell S. Taichman From the Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor. The mechanisms of bone and blood formation have traditionally been viewed as distinct, unrelated processes, but compelling evidence suggests that they are intertwined. Based on observations that hematopoietic precursors reside close to endosteal surfaces, it was hypothesized that osteoblasts play a central role in hematopoiesis, and it has been shown that osteoblasts produce many factors essential for the survival, renewal, and maturation of hematopoietic stem cells (HSCs). Preceding these observations are studies demonstrating that the disruption or perturbation of normal osteoblastic function has a profound and central role in defining the operational structure of the HSC niche. These observations provide a glimpse of the dimensions and ramifications of HSC-osteoblast interactions. Although more research is required to secure a broader grasp of the molecular mechanisms that govern blood and bone biology, the central role for osteoblasts in hematopoietic stem cell regulation is reviewed herein from the perspectives of (1) historical context; (2) the role of the osteoblast in supporting stem cell survival, proliferation, and maintenance; (3) the participation, if any, of osteoblasts in the creation of a stem cell niche; (4) the molecules that mediate HSC-osteoblast interactions; (5) the role of osteoblasts in stem cell transplantation; and (6) possible future directions for investigation. 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