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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2677-2684. Prepublished online as a Blood First Edition Paper on December 9, 2004; DOI 10.1182/blood-2004-10-3883. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-10-3883v1 105/7/2677    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dreyling, M. Articles by Hiddemann, W. Search for Related Content PubMed PubMed Citation Articles by Dreyling, M. Articles by Hiddemann, W. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network Martin Dreyling, Georg Lenz, Eva Hoster, Achiel Van Hoof, Christian Gisselbrecht, Rudolf Schmits, Bernd Metzner, Lorenz Truemper, Marcel Reiser, Hjalmar Steinhauer, Jean-Michel Boiron, Marc A. Boogaerts, Ali Aldaoud, Vittorio Silingardi, Hanneke C. Kluin-Nelemans, Joerg Hasford, Reza Parwaresch, Michael Unterhalt, and Wolfgang Hiddemann From the Department of Internal Medicine III, Ludwig-Maximilians University, Munich, Germany; Department of Medical Informatics, Biometrics and Epidemiology (IBE), Ludwig-Maximilians University, Munich, Germany; Department of Hematology, Hopital St-Jan, Brugge, Belgium; Department of Hematology, Hopital Saint Louis, Paris, France; Department of Hematology and Oncology, University of Saarland, Homburg/Saar, Germany; Department of Internal Medicine II, Klinikum Oldenburg, Germany; Department of Hematology and Oncology, Georg August University, Goettingen, Germany; Department of Internal Medicine I, University of Cologne, Germany; Department of Internal Medicine II, Carl-Thiem Klinikum, Cottbus, Germany; Haut-Leveque Hospital, University of Bordeaux, France; Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium; Praxis für Hämatologie/Onkologie, Leipzig, Germany; Department of Medical Oncology, University of Modena, Italy; Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands; and Department of Hematopathology, University of Kiel, Germany. Mantle-cell lymphoma (MCL) is characterized by poor prognosis with a median survival of only 3 to 4 years. To improve clinical outcome, the European MCL Network initiated a randomized trial comparing consolidation with myeloablative radiochemotherapy followed by autologous stem cell transplantation (ASCT) to -interferon maintenance (IFN) in first remission. Patients 65 years of age or younger with advanced-stage MCL were assigned to ASCT or IFN after achievement of complete or partial remission by a cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP)–like induction therapy. According to the International Prognostic Index (IPI), 43% of patients had a low-risk, 41% a low-intermediate, 11% a high-intermediate, and 6% a high-risk profile. Sixty-two of 122 patients proceeded to ASCT and 60 received IFN. Patients in the ASCT arm experienced a significantly longer progression-free survival (PFS) with a median of 39 months compared with 17 months for patients in the IFN arm (P = .0108). The 3-year overall survival (OS) was 83% after ASCT versus 77% in the IFN group (P = .18). Early consolidation by myeloablative radiochemotherapy followed by ASCT is feasible and results in a significant prolongation of PFS in advanced-stage MCL. Longer follow-up is needed to determine the effect on OS. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. R. Appelbaum Hematopoietic Cell Transplantation for Non-Hodgkin's Lymphoma: Yesterday, Today, and Tomorrow J. Clin. Oncol., June 20, 2008; 26(18): 2927 - 2929. [Full Text] [PDF] F. Buchegger, O. W. Press, A. B. Delaloye, and N. Ketterer Radiolabeled and Native Antibodies and the Prospect of Cure of Follicular Lymphoma Oncologist, June 1, 2008; 13(6): 657 - 667. [Abstract] [Full Text] [PDF] S. Bottcher, M. Ritgen, S. Buske, S. Gesk, W. Klapper, E. Hoster, W. Hiddemann, M. Unterhalt, M. Dreyling, R. Siebert, et al. Minimal residual disease detection in mantle cell lymphoma: methods and significance of four-color flow cytometry compared to consensus IGH-polymerase chain reaction at initial staging and for follow-up examinations Haematologica, April 1, 2008; 93(4): 551 - 559. [Abstract] [Full Text] [PDF] O. Determann, E. Hoster, G. Ott, H. Wolfram Bernd, C. Loddenkemper, M. Leo Hansmann, T. E. F. Barth, M. Unterhalt, W. Hiddemann, M. Dreyling, et al. Ki-67 predicts outcome in advanced-stage mantle cell lymphoma patients treated with anti-CD20 immunochemotherapy: results from randomized trials of the European MCL Network and the German Low Grade Lymphoma Study Group Blood, February 15, 2008; 111(4): 2385 - 2387. [Abstract] [Full Text] [PDF] E. Hoster, M. Dreyling, W. Klapper, C. Gisselbrecht, A. van Hoof, H. C. Kluin-Nelemans, M. Pfreundschuh, M. 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