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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2836-2844. Prepublished online as a Blood First Edition Paper on December 2, 2004; DOI 10.1182/blood-2004-07-2878. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-07-2878v1 105/7/2836    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wang, T. Articles by Kelly, K. Search for Related Content PubMed PubMed Citation Articles by Wang, T. Articles by Kelly, K. Related Collections Hemostasis, Thrombosis, and Vascular Biology Immunobiology Cell Adhesion and Motility Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells Tao Wang, Yvona Ward, Linhua Tian, Ross Lake, Liliana Guedez, William G. Stetler-Stevenson, and Kathleen Kelly From the Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD. CD97, a membrane protein expressed at high levels on inflammatory cells and some carcinomas, is a member of the adhesion G protein–coupled receptor family, whose members have bipartite structures consisting of an extracellular peptide containing adhesion motifs noncovalently coupled to a class B 7-transmembrane domain. CD97, the extracellular domain of CD97, contains 3 to 5 fibrillin class 1 epidermal growth factor (EGF)–like repeats, an Arg-Gly-Asp (RGD) tripeptide, and a mucin stalk. We show here that CD97 promotes angiogenesis in vivo as demonstrated with purified protein in a directed in vivo angiogenesis assay (DIVAA) and by enhanced vascularization of developing tumors expressing CD97. These data suggest that CD97 can contribute to angiogenesis associated with inflammation and tumor progression. Strong integrin 51 interactions with CD97 have been identified, but v3 also contributes to cell attachment. Furthermore, soluble CD97 acts as a potent chemoattractant for migration and invasion of human umbilical vein endothelial cells (HUVECs), and this function is integrin dependent. CD97 EGF-like repeat 4 is known to bind chondroitin sulfate. It was found that coengagement of 51 and chondroitotin sulfate proteoglycan by CD97 synergistically initiates endothelial cell invasion. Integrin 51 is the first high-affinity cellular counterreceptor that has been identified for a member within this family of adhesion receptors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Yona, H.-H. Lin, P. Dri, J. Q. Davies, R. P. G. Hayhoe, S. M. Lewis, S. E. M. Heinsbroek, K. A. Brown, M. Perretti, J. Hamann, et al. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function FASEB J, March 1, 2008; 22(3): 741 - 751. [Abstract] [Full Text] [PDF] M. Chrzanowska-Wodnicka, A. E. Kraus, D. Gale, G. C. White II, and J. VanSluys Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice Blood, March 1, 2008; 111(5): 2647 - 2656. [Abstract] [Full Text] [PDF] Z. Jin, I. Tietjen, L. Bu, L. Liu-Yesucevitz, S. K. Gaur, C. A. Walsh, and X. Piao Disease-associated mutations affect GPR56 protein trafficking and cell surface expression Hum. Mol. 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Essler Proteolytically Processed Soluble Tumor Endothelial Marker (TEM) 5 Mediates Endothelial Cell Survival during Angiogenesis by Linking Integrin {alpha}vbeta3 to Glycosaminoglycans J. Biol. Chem., November 10, 2006; 281(45): 34179 - 34188. [Abstract] [Full Text] [PDF] J. Galle, D. Sittig, I. Hanisch, M. Wobus, E. Wandel, M. Loeffler, and G. Aust Individual Cell-Based Models of Tumor-Environment Interactions: Multiple Effects of CD97 on Tumor Invasion Am. J. Pathol., November 1, 2006; 169(5): 1802 - 1811. [Abstract] [Full Text] [PDF] M. Capasso, L. G. Durrant, M. Stacey, S. Gordon, J. Ramage, and I. Spendlove Costimulation via CD55 on Human CD4+ T Cells Mediated by CD97 J. Immunol., July 15, 2006; 177(2): 1070 - 1077. [Abstract] [Full Text] [PDF]

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