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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2955-2962. Prepublished online as a Blood First Edition Paper on December 14, 2004; DOI 10.1182/blood-2004-07-2520. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: 2004-07-2520v1 105/7/2955    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Viemann, D. Articles by Roth, J. Search for Related Content PubMed PubMed Citation Articles by Viemann, D. Articles by Roth, J. Related Collections Hemostasis, Thrombosis, and Vascular Biology Phagocytes Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PHAGOCYTES Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells Dorothee Viemann, Anke Strey, Annette Janning, Kerstin Jurk, Kerstin Klimmek, Thomas Vogl, Keiichi Hirono, Fukiko Ichida, Dirk Foell, Beate Kehrel, Volker Gerke, Clemens Sorg, and Johannes Roth From the Institute of Experimental Dermatology, the Institute of Medical Biochemistry/Center for Molecular Biology of Inflammation, Integrated Functional Genomics, and the Interdisciplinary Clinical Research Center, University of Muenster; the Department of Pediatrics and the Department of Anaesthesiology and Intensive Care, Experimental and Clinical Haemostasis, University Hospital Muenster, Germany; and the Department of Pediatrics, Toyama Medical and Pharmaceutical University, Japan. Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated phagocytes, bind specifically to endothelial cells. The endothelial response to MRP8/MRP14, however, is unknown. Using oligonucleotide microarray analysis, we show for the first time that MRP8/MRP14 induce a thrombogenic, inflammatory response in human microvascular endothelial cells by increasing the transcription of proinflammatory chemokines and adhesion molecules and by decreasing the expression of cell junction proteins and molecules involved in monolayer integrity. All changes on the gene expression level could be confirmed using biochemical and functional assays. We demonstrated that the expression of MRP8/MRP14 closely correlated with the inflammatory activity in systemic vasculitis, confirming the important role of these proteins for distinct inflammatory reactions in endothelia. MRP8/MRP14 may represent novel targets for anti-inflammatory strategies. 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