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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2973-2978. Prepublished online as a Blood First Edition Paper on December 21, 2004; DOI 10.1182/blood-2004-09-3660. This Article Full Text Full Text (PDF) Supplemental Data Set All Versions of this Article: 2004-09-3660v1 105/7/2973    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Miklos, D. B. Articles by Ritz, J. Search for Related Content PubMed PubMed Citation Articles by Miklos, D. B. Articles by Ritz, J. Related Collections Transplantation Clinical Trials and Observations Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission David B. Miklos, Haesook T. Kim, Katherine H. Miller, Luxuan Guo, Emmanuel Zorn, Stephanie J. Lee, Ephraim P. Hochberg, Catherine J. Wu, Edwin P. Alyea, Corey Cutler, Vincent Ho, Robert J. Soiffer, Joseph H. Antin, and Jerome Ritz From the Departments of Medical Oncology and Biostatistical Science, Dana-Farber Cancer Institute; the Department of Medicine, Brigham and Women's Hospital; and Harvard Medical School, Boston, MA. Minor histocompatibility antigens (mHAs) are known targets of donor T cells after allogeneic hematopoietic stem cell transplantation (HSCT). In contrast, B-cell responses to mHAs have not been extensively characterized and the clinical significance of antibodies to mHAs is unknown. We tested 121 patients who underwent HSCT and 134 healthy donors for immunoglobulin G (IgG) antibodies against 5 mHAs encoded by genes on the Y chromosome (DBY, UTY, ZFY, RPS4Y, and EIF1AY). Antibodies to at least one H-Y protein developed in 52% of male patients with female donors compared with 8.7% of male patients with male donors (P < .0001), and in 41.4% of healthy females compared with 7.8% of healthy males (P < .0001). H-Y antibodies develop 4 to 12 months after transplantation and persist for long periods. The clinical significance of H-Y antibodies was characterized in 75 male patients with hematologic malignancies who received stem cells from female donors (F M HSCT). The presence of H-Y antibodies correlated with chronic graft-versus-host disease (GVHD) by univariate (odds ratio [OR] = 15.5; P < .0001) and multivariable logistic regression analysis (OR = 56.5; P < .0001). Antibody response to Y-chromosome encoded histocompatibility antigens (H-Y antigens) was also associated with maintenance of disease remission (P < .0001). B cells may provide a new target for immune intervention in chronic GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: GVHD and relapse: to B or not to B Stephen G. Emerson Blood 2005 105: 2627-2628. [Full Text] [PDF] This article has been cited by other articles: B. Friedrichs, S. Siegel, M. Kloess, A. Barsoum, J. Coggin Jr., J. Rohrer, I. Jakob, M. Tiemann, K. Heidorn, C. Schulte, et al. Humoral Immune Responses against the Immature Laminin Receptor Protein Show Prognostic Significance in Patients with Chronic Lymphocytic Leukemia J. 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