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Blood, 15 April 2005, Vol. 105, No. 8, pp. 3019-3025. Prepublished online as a Blood First Edition Paper on December 16, 2004; DOI 10.1182/blood-2004-09-3475. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-09-3475v1 105/8/3019    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sanz, M. A. Articles by Lo-Coco, F. Search for Related Content PubMed PubMed Citation Articles by Sanz, M. A. Articles by Lo-Coco, F. Related Collections Perspectives Neoplasia Oncogenes and Tumor Suppressors Free Research Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PERSPECTIVES Tricks of the trade for the appropriate management of newly diagnosed acute promyelocytic leukemia Miguel A. Sanz, Martin S. Tallman, and Francesco Lo-Coco From the Hematology Service, University Hospital La Fe, Valencia, Spain; the Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL; and the Dipartimento di Biopatologia e Diagnostica per Immagini, University "Tor Vergata," Rome, Italy. Abstract Most reviews on the state-of-the-art treatment in acute promyelocytic leukemia (APL) have focused mainly on the comparison of therapeutic approaches, including all-trans retinoic acid (ATRA) and chemotherapy. However, outcome of individual patients also depends on appropriate knowledge of several aspects related to APL management that are less appreciated and/or are underestimated in the literature. These aspects include appropriate diagnostic strategy, use of supportive care, early recognition and treatment of life-threatening complications typically associated with APL and its specific treatment, tools and timing for adequate evaluation of response, and, finally, management of the disease in special conditions such as older patients and pregnant women. Besides reviewing current consensus and controversies on the use of ATRA and chemotherapy in the distinct treatment phases (eg, induction, consolidation, maintenance), this article addresses the aforementioned issues on APL management ("tricks of the trade") with special emphasis on several peculiar aspects that distinguish APL from other acute myeloid leukemias. 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