|
|
Blood, 1 July 2005, Vol. 106, No. 1, pp. 207-215.
Prepublished online as a Blood First Edition Paper on March 22, 2005; DOI 10.1182/blood-2004-12-4943.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a
Kayoko Sato,
Yasuyuki Imai,
Nobuaki Higashi,
Yosuke Kumamoto,
Thandi M. Onami,
Stephen M. Hedrick, and
Tatsuro Irimura
From the Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan; the Department of Microbiology, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka, Japan; and the Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA.
Macrophage galactose-type C-type lectins (MGLs), which were recently named CD301, have 2 homologues in mice: MGL1 and MGL2. MGLs are expressed on macrophages and immature dendritic cells. The persistent presence of granulation tissue induced by a protein antigen was observed in wild-type mice but not in mice lacking an endogenous, macrophage-specific, galactose-type calcium-type lectin 1 (MGL1) in an air pouch model. The anti-MGL1 antibody suppressed the granulation tissue formation in wild-type mice. A large number of cells, present only in the pouch of MGL1-deficient mice, were not myeloid or lymphoid lineage cells and the number significantly declined after administration of interleukin 1  (IL-1) into the pouch of MGL1-deficient mice. Furthermore, granulation tissue was restored by this treatment and the cells obtained from the pouch of MGL1-deficient mice were incorporated into the granulation tissue when injected with IL-1. Taken together, MGL1 expressed on a specific subpopulation of macrophages that secrete IL-1 was proposed to regulate specific cellular interactions crucial to granulation tissue formation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K. Saba, K. Denda-Nagai, and T. Irimura
A C-Type Lectin MGL1/CD301a Plays an Anti-Inflammatory Role in Murine Experimental Colitis
Am. J. Pathol.,
January 1, 2009;
174(1):
144 - 152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Holt, L. Cheng, and C. Ju
Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury
J. Leukoc. Biol.,
December 1, 2008;
84(6):
1410 - 1421.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. N. Lumeng, J. B. DelProposto, D. J. Westcott, and A. R. Saltiel
Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes
Diabetes,
December 1, 2008;
57(12):
3239 - 3246.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Sano, K. Usami, R. Izawa, K. Denda-Nagai, N. Higashi, T. Kimura, N. Suzuki, and T. Irimura
Properties of Blocking and Non-blocking Monoclonal Antibodies Specific for Human Macrophage Galactose-type C-type Lectin (MGL/ClecSF10A/CD301)
J. Biochem.,
January 1, 2007;
141(1):
127 - 136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Yuita, M. Tsuiji, Y. Tajika, Y. Matsumoto, K. Hirano, N. Suzuki, and T. Irimura
Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos
Glycobiology,
December 1, 2005;
15(12):
1368 - 1375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
