SEARCH:   Advanced

Blood, 1 July 2005, Vol. 106, No. 1, pp. 207-215. Prepublished online as a Blood First Edition Paper on March 22, 2005; DOI 10.1182/blood-2004-12-4943. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-12-4943v1 106/1/207    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sato, K. Articles by Irimura, T. Search for Related Content PubMed PubMed Citation Articles by Sato, K. Articles by Irimura, T. Related Collections Immunobiology Phagocytes Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a Kayoko Sato, Yasuyuki Imai, Nobuaki Higashi, Yosuke Kumamoto, Thandi M. Onami, Stephen M. Hedrick, and Tatsuro Irimura From the Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan; the Department of Microbiology, University of Shizuoka, School of Pharmaceutical Sciences, Shizuoka, Japan; and the Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA. Macrophage galactose-type C-type lectins (MGLs), which were recently named CD301, have 2 homologues in mice: MGL1 and MGL2. MGLs are expressed on macrophages and immature dendritic cells. The persistent presence of granulation tissue induced by a protein antigen was observed in wild-type mice but not in mice lacking an endogenous, macrophage-specific, galactose-type calcium-type lectin 1 (MGL1) in an air pouch model. The anti-MGL1 antibody suppressed the granulation tissue formation in wild-type mice. A large number of cells, present only in the pouch of MGL1-deficient mice, were not myeloid or lymphoid lineage cells and the number significantly declined after administration of interleukin 1 (IL-1) into the pouch of MGL1-deficient mice. Furthermore, granulation tissue was restored by this treatment and the cells obtained from the pouch of MGL1-deficient mice were incorporated into the granulation tissue when injected with IL-1. Taken together, MGL1 expressed on a specific subpopulation of macrophages that secrete IL-1 was proposed to regulate specific cellular interactions crucial to granulation tissue formation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Saba, K. Denda-Nagai, and T. Irimura A C-Type Lectin MGL1/CD301a Plays an Anti-Inflammatory Role in Murine Experimental Colitis Am. J. Pathol., January 1, 2009; 174(1): 144 - 152. [Abstract] [Full Text] [PDF] Y. Sano, K. Usami, R. Izawa, K. Denda-Nagai, N. Higashi, T. Kimura, N. Suzuki, and T. Irimura Properties of Blocking and Non-blocking Monoclonal Antibodies Specific for Human Macrophage Galactose-type C-type Lectin (MGL/ClecSF10A/CD301) J. Biochem., January 1, 2007; 141(1): 127 - 136. [Abstract] [Full Text] [PDF] H. Yuita, M. Tsuiji, Y. Tajika, Y. Matsumoto, K. Hirano, N. Suzuki, and T. Irimura Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos Glycobiology, December 1, 2005; 15(12): 1368 - 1375. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020