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 Blood, 1 July 2005, Vol. 106, No. 1, pp. 353-355.
Prepublished online as a Blood First Edition Paper on March 10, 2005; DOI 10.1182/blood-2005-01-0033.

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NEOPLASIA
Brief report

Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma

Hong Chang, A. Keith Stewart, Xiao Ying Qi, Zhi Hua Li, Qi Long Yi, and Suzanne Trudel

From the Department of Laboratory Hematology, Department of Laboratory Medicine and Pathobiology, Department of Medical Oncology and Hematology, and Department of Biostatistics, Princess Margaret Hospital/University Health Network, McLaughlin Center for Molecular Medicine, University of Toronto, ON, Canada.

The t(4;14) translocation detected by fluorescence in situ hybridization (FISH) is an independent prognostic factor for an adverse outcome of multiple myeloma (MM). Because t(4;14) uniquely results in fibroblast growth factor receptor 3 (FGFR3) expression, decalcified, paraffin-embedded bone marrow biopsies were immunostained for FGFR3, and its expression was correlated with the t(4;14) status. FISH detected t(4;14) in 16 (19%) of 85 MM patient specimens, and immunocytochemistry detected aberrant FGFR3 expression in 13 (15%). Twelve (75%) t(4;14)-positive cases expressed FGFR3, and 12 (92%) FGFR3-positive cases harbored a t(4;14). FGFR3 expression and t(4;14) were strongly correlated (P < .001). FGFR3 expression by immunohistochemistry was associated with the immunoglobulin A (IgA) isotype (P < .001), a shorter progression-free survival (median, 11.5 versus 25.8 months; P < .001), and a shorter overall survival (median, 19.2 versus 46.3 months; P < .001).


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