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Blood, 1 July 2005, Vol. 106, No. 1, pp. 372-375. Prepublished online as a Blood First Edition Paper on March 22, 2005; DOI 10.1182/blood-2005-02-0548. This Article Full Text Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: 2005-02-0548v1 106/1/372    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Baldwin, C. Articles by Steinberg, M. H. Search for Related Content PubMed PubMed Citation Articles by Baldwin, C. Articles by Steinberg, M. H. Related Collections Red Cells Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Brief report Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis Clinton Baldwin, Vikki G. Nolan, Diego F. Wyszynski, Qian-Li Ma, Paola Sebastiani, Stephen H. Embury, Alice Bisbee, John Farrell, Lindsay Farrer, and Martin H. Steinberg From the Center for Human Genetics, Departments of Pediatrics and Medicine, Boston University School of Medicine, Boston, MA; the Boston University School of Public Health, Boston, MA; and the Department of Medicine, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA. In patients with sickle cell disease, clinical complications including osteonecrosis can vary in frequency and severity, presumably due to the effects of genes that modify the pathophysiology initiated by the sickle mutation. Here, we examined the association of single nucleotide polymorphisms (SNPs) in candidate genes (cytokines, inflammation, oxidant stress, bone metabolism) with osteonecrosis in patients with sickle cell disease. Genotype distributions were compared between cases and controls using multiple logistic regression techniques. An initial screen and follow-up studies showed that individual SNPs and haplotypes composed of several SNPs in bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis. These genes are important in bone morphology, metabolism, and vascular disease. Our results may provide insight into the pathogenesis of osteonecrosis in sickle cell disease, help identify individuals who are at high risk for osteonecrosis, and thus allow earlier and more effective therapeutic intervention. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. A. Mont, L. C. Jones, and D. S. Hungerford Nontraumatic Osteonecrosis of the Femoral Head: Ten Years Later J. Bone Joint Surg. Am., May 1, 2006; 88(5): 1117 - 1132. [Abstract] [Full Text] [PDF] P. Sebastiani, C. T. Baldwin, V. Nolan, D. F. Wyszynski, Q.-L. Ma, J. Farrell, A. Bisbee, K. Waraska, L. A. Farrer, and M. H. Steinberg Polymorphisms (Snps) in Multiple Genes of the Tgf-{beta}/Bmp Pathway Are Associated with a Global Measure of Sickle Cell Disease Severity. Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 74 - 74. [Abstract] V. G. Nolan, A. C. Rybicki, C. T. Baldwin, H. T. Cohen, A. H. Adewoye, D. F. Wyszynski, M. E. Fabry, R. L. Nagel, and M. H. Steinberg Creatinine Clearance in Sickle Cell Anemia Is Modulated by Genes in the TGF-{beta}/BMP Pathway. Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 3175 - 3175. [Abstract]

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