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Blood, 15 November 2005, Vol. 106, No. 10, pp. 3405-3409. Prepublished online as a Blood First Edition Paper on August 11, 2005; DOI 10.1182/blood-2005-01-0254. This Article Full Text Full Text (PDF) Supplemental Table and Figure All Versions of this Article: 2005-01-0254v1 106/10/3405    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Niemelä, H. Articles by Jalkanen, S. Search for Related Content PubMed PubMed Citation Articles by Niemelä, H. Articles by Jalkanen, S. Related Collections Hemostasis, Thrombosis, and Vascular Biology Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Molecular identification of PAL-E, a widely used endothelial-cell marker Harri Niemelä, Kati Elima, Tiina Henttinen, Heikki Irjala, Marko Salmi, and Sirpa Jalkanen From the MediCity Research Laboratory, Turku University, Turku, Finland; and the National Public Health Institute, Turku, Finland. The pathologische anatomie Leiden-endothelium (PAL-E) antibody has been used for almost 20 years as a specific marker for vascular endothelial cells. Due to the fact that this antibody works only in very limited applications, the molecular identity of PAL-E has remained unknown. In this work, we demonstrate by double stainings, cross-immunoprecipitations, and transfectants that the PAL-E antigen is identical with a protein designated PV-1 (plasmalemmal vesicle 1) or FELS (fenestrated endothelial-linked structure protein) and is not vimentin, as reported earlier. As the expression of this molecule is by no means restricted to fenestrated endothelium, we suggest the use of the name PLVAP for this protein. Molecular identification of PLVAP should help in the production of new tools for the identification of vascular as opposed to lymphatic endothelium and to elucidate the function of this protein. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Keuschnigg, T. Henttinen, K. Auvinen, M. Karikoski, M. Salmi, and S. Jalkanen The prototype endothelial marker PAL-E is a leukocyte trafficking molecule Blood, July 9, 2009; 114(2): 478 - 484. [Abstract] [Full Text] [PDF] S. Mellberg, A. Dimberg, F. Bahram, M. Hayashi, E. Rennel, A. Ameur, J. O. Westholm, E. Larsson, P. Lindahl, M. J. Cross, et al. Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis FASEB J, May 1, 2009; 23(5): 1490 - 1502. [Abstract] [Full Text] [PDF] S. C. Satchell and F. Braet Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier Am J Physiol Renal Physiol, May 1, 2009; 296(5): F947 - F956. [Abstract] [Full Text] [PDF] N. F. Schafer, U. F. O. Luhmann, S. Feil, and W. Berger Differential Gene Expression in Ndph-Knockout Mice in Retinal Development Invest. Ophthalmol. Vis. Sci., February 1, 2009; 50(2): 906 - 916. [Abstract] [Full Text] [PDF] S. Marmon, J. Hinchey, P. Oh, M. Cammer, C. J. de Almeida, L. Gunther, C. S. Raine, and M. P. Lisanti Caveolin-1 Expression Determines the Route of Neutrophil Extravasation through Skin Microvasculature Am. J. Pathol., February 1, 2009; 174(2): 684 - 692. [Abstract] [Full Text] [PDF] D. E. Jaalouk, M. G. Ozawa, J. Sun, J. Lahdenranta, R. O. Schlingemann, R. Pasqualini, and W. Arap The Original Pathologische Anatomie Leiden-Endothelium Monoclonal Antibody Recognizes a Vascular Endothelial Growth Factor Binding Site within Neuropilin-1 Cancer Res., October 15, 2007; 67(20): 9623 - 9629. [Abstract] [Full Text] [PDF] L. A. Johnson, S. Clasper, A. P. Holt, P. F. Lalor, D. Baban, and D. G. Jackson An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium J. Exp. Med., November 27, 2006; 203(12): 2763 - 2777. [Abstract] [Full Text] [PDF]

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