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Blood, 15 November 2005, Vol. 106, No. 10, pp. 3546-3552. Prepublished online as a Blood First Edition Paper on July 28, 2005; DOI 10.1182/blood-2005-02-0493. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-02-0493v1 106/10/3546    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Glud, S. Z. Articles by Pedersen, F. S. Search for Related Content PubMed PubMed Citation Articles by Glud, S. Z. Articles by Pedersen, F. S. Related Collections Neoplasia Oncogenes and Tumor Suppressors Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus Sys Zoffmann Glud, Annette Balle Sørensen, Mindaugas Andrulis, Bruce Wang, Eisaku Kondo, Randi Jessen, Laszlo Krenacs, Eva Stelkovics, Matthias Wabl, Edgar Serfling, Alois Palmetshofer, and Finn Skou Pedersen From the Department of Molecular Biology, University of Aarhus, Aarhus, Denmark; the Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany; Picobella, Burlingame, CA; the Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan; the Laboratory of Tumor Pathology and Molecular Diagnostics, Institute of Biotechnology, Bay Zoltan Foundation for Applied Research, Szeged, Hungary; the Department of Microbiology and Immunology, University of California, San Francisco, CA; and the Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark. Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. H. Rasmussen, B. Wang, M. Wabl, A. L. Nielsen, and F. S. Pedersen Activation of alternative Jdp2 promoters and functional protein isoforms in T-cell lymphomas by retroviral insertion mutagenesis Nucleic Acids Res., June 15, 2009; (2009) gkp469v2. [Abstract] [Full Text] [PDF] A. H.T. Nguyen, M. Beland, Y. Gaitan, and M. Bouchard Calcineurin A-Binding Protein, a Novel Modulator of the Calcineurin-Nuclear Factor of Activated T-Cell Signaling Pathway, Is Overexpressed in Wilms' Tumors and Promotes Cell Migration Mol. Cancer Res., June 1, 2009; 7(6): 821 - 831. [Abstract] [Full Text] [PDF] D. Ejegod, K. D. Sorensen, I. Mossbrugger, L. Quintanilla-Martinez, J. Schmidt, and F. S. Pedersen Control of Pathogenicity and Disease Specificity of a T-Lymphomagenic Gammaretrovirus by E-Box Motifs but Not by an Overlapping Glucocorticoid Response Element J. Virol., January 1, 2009; 83(1): 336 - 346. [Abstract] [Full Text] [PDF] A. Akimzhanov, L. Krenacs, T. Schlegel, S. Klein-Hessling, E. Bagdi, E. Stelkovics, E. Kondo, S. Chuvpilo, P. Wilke, A. Avots, et al. Epigenetic Changes and Suppression of the Nuclear Factor of Activated T Cell 1 (NFATC1) Promoter in Human Lymphomas with Defects in Immunoreceptor Signaling Am. J. Pathol., January 1, 2008; 172(1): 215 - 224. [Abstract] [Full Text] [PDF] K. Yao, Y.-Y. Cho, H. R. Bergen III, B. J. Madden, B. Y. Choi, W.-Y. Ma, A. M. Bode, and Z. Dong Nuclear Factor of Activated T3 Is a Negative Regulator of Ras-JNK1/2-AP-1 Induced Cell Transformation Cancer Res., September 15, 2007; 67(18): 8725 - 8735. [Abstract] [Full Text] [PDF] B. Dong, S. Kim, S. Hong, J. Das Gupta, K. Malathi, E. A. Klein, D. Ganem, J. L. DeRisi, S. A. Chow, and R. H. Silverman From the Cover: An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors PNAS, January 30, 2007; 104(5): 1655 - 1660. [Abstract] [Full Text] [PDF] C. L. Wang, B. B. Wang, G. Bartha, L. Li, N. Channa, M. Klinger, N. Killeen, and M. Wabl Activation of an oncogenic microRNA cistron by provirus integration PNAS, December 5, 2006; 103(49): 18680 - 18684. [Abstract] [Full Text] [PDF]

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