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 Blood, 15 November 2005, Vol. 106, No. 10, pp. 3546-3552.
Prepublished online as a Blood First Edition Paper on July 28, 2005; DOI 10.1182/blood-2005-02-0493.

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NEOPLASIA

A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus

Sys Zoffmann Glud, Annette Balle Sørensen, Mindaugas Andrulis, Bruce Wang, Eisaku Kondo, Randi Jessen, Laszlo Krenacs, Eva Stelkovics, Matthias Wabl, Edgar Serfling, Alois Palmetshofer, and Finn Skou Pedersen

From the Department of Molecular Biology, University of Aarhus, Aarhus, Denmark; the Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany; Picobella, Burlingame, CA; the Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan; the Laboratory of Tumor Pathology and Molecular Diagnostics, Institute of Biotechnology, Bay Zoltan Foundation for Applied Research, Szeged, Hungary; the Department of Microbiology and Immunology, University of California, San Francisco, CA; and the Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark.

Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.


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