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Blood, 15 November 2005, Vol. 106, No. 10, pp. 3632-3638. Prepublished online as a Blood First Edition Paper on July 26, 2005; DOI 10.1182/blood-2005-04-1574. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-04-1574v1 106/10/3632    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Layez, C. Articles by Gysin, J. Search for Related Content PubMed PubMed Citation Articles by Layez, C. Articles by Gysin, J. Related Collections Immunobiology Phagocytes Red Cells Free Research Articles Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Plasmodium falciparum rhoptry protein RSP2 triggers destruction of the erythroid lineage Corinne Layez, Paulo Nogueira, Valery Combes, Fabio T. M. Costa, Irène Juhan-Vague, Luiz H. Pereira da Silva, and Jürg Gysin From the Unité de Parasitologie Expérimentale Unite de Recherche Associée (URA) Institut Pasteur/Univ. Med. Equipe d'Accueil (EA3282), Institut Fédératif de Recherche (IFR48), Faculté de Médecine, Université de la Méditérranée (Aix-Marseille II), Marseille, France; Unidade de Imunologia E Parasitologia Experimental, Centro de Pesquisa em Medicina Tropical (CEPEM)–BR 364, Rondônia, Brazil; Departamento de Parasitologia, Universidade Estadual de Campinas, Campinas, Brazil; Laboratoire d'Hématologie, Faculté de Médecine, Université de la Méditerranée, Marseille, France. The destruction of erythrocytes and defects in erythropoiesis are among the most frequently observed causes of morbidity in severe Plasmodium falciparum malaria. The molecular mechanisms involved remain unclear, despite extensive investigation. We show here, for the first time, that tagging with the parasite rhoptry protein ring surface protein 2 (RSP2) is not restricted to the surfaces of normal erythrocytes, as previously reported, but that it extends to erythroid precursor cells in the bone marrow of anemic malaria patients. Monoclonal mouse antibodies and human sera from patients with severe anemia, reacting with RSP2-tagged erythrocytes, induced cell destruction by phagocytosis and complement activation in vitro. Our observations reveal a new parasite mechanism implicated in the destruction of normal erythrocytes and probably dyserythropoiesis in malaria patients. These data suggest that the tagging of host cells with RSP2 may trigger anemia in falciparum malaria. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Severe anemia in malaria: defense gone wrong? Gerhard Winter and Mats Wahlgren Blood 2005 106: 3337-3338. [Full Text] [PDF] This article has been cited by other articles: A. A. Lamikanra, D. Brown, A. Potocnik, C. Casals-Pascual, J. Langhorne, and D. J. Roberts Malarial anemia: of mice and men Blood, July 1, 2007; 110(1): 18 - 28. [Abstract] [Full Text] [PDF] J. W. Barnwell Malaria: death and disappearing erythrocytes Blood, February 1, 2006; 107(3): 854 - 855. [Full Text] [PDF] K. J. Evans, D. S. Hansen, N. van Rooijen, L. A. Buckingham, and L. Schofield Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes Blood, February 1, 2006; 107(3): 1192 - 1199. [Abstract] [Full Text] [PDF]

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