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Blood, 1 December 2005, Vol. 106, No. 12, pp. 4009-4015. Prepublished online as a Blood First Edition Paper on August 16, 2005; DOI 10.1182/blood-2005-06-2339. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-06-2339v1 106/12/4009    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dutt, S. Articles by Strober, S. Search for Related Content PubMed PubMed Citation Articles by Dutt, S. Articles by Strober, S. Related Collections Immunobiology Transplantation Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents TRANSPLANTATION L-selectin and 7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease Suparna Dutt, Joerg Ermann, Diane Tseng, Yin Ping Liu, Tracy I. George, C. Garrison Fathman, and Samuel Strober From the Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA. The homing receptors L-selectin and 47 integrin facilitate entry of T cells into the gut-associated organized lymphoid tissues such as the mesenteric lymph nodes and Peyer patches. We studied the impact of inactivation of genes encoding these receptors on the ability of purified donor CD4+ T cells to induce acute lethal graft-versus-host disease (GVHD) associated with severe colitis in irradiated major histocompatibility complex (MHC)–mismatched mice. Whereas lack of expression of a single receptor had no significant impact on the severity of colitis and GVHD, the lack of expression of both receptors markedly ameliorated colitis and early deaths observed with wild-type (WT) T cells. The changes in colitis and GVHD were reflected in a marked reduction in the early accumulation of donor T cells in the mesenteric lymph nodes and subsequently in the colon. The purified WT donor CD4+ T cells did not accumulate early in the Peyer patches and failed to induce acute injury to the small intestine. In conclusion, the combination of CD62L and 7 integrin is required to induce acute colitis and facilitate entry of CD4+ donor T cells in the mesenteric nodes associated with lethal GVHD in allogeneic hosts. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Filatenkov, A. M. S. Muller, W. W.-L. Tseng, S. Dejbakhsh-Jones, D. Winer, R. Luong, J. A. Shizuru, E. G. Engleman, and S. Strober Ineffective Vaccination against Solid Tumors Can Be Enhanced by Hematopoietic Cell Transplantation J. Immunol., December 1, 2009; 183(11): 7196 - 7203. [Abstract] [Full Text] [PDF] G. Socie and B. R. Blazar Acute graft-versus-host disease: from the bench to the bedside Blood, November 12, 2009; 114(20): 4327 - 4336. [Abstract] [Full Text] [PDF] H. Zheng, C. Matte-Martone, D. Jain, J. McNiff, and W. D. Shlomchik Central Memory CD8+ T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia J. 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