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Blood, 15 December 2005, Vol. 106, No. 13, pp. 4249-4252. Prepublished online as a Blood First Edition Paper on August 25, 2005; DOI 10.1182/blood-2005-06-2327. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-06-2327v1 106/13/4249    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chaganti, S. Articles by Rickinson, A. B. Search for Related Content PubMed PubMed Citation Articles by Chaganti, S. Articles by Rickinson, A. B. Related Collections Neoplasia Brief Reports Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief report Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes Sridhar Chaganti, Andrew I. Bell, Noelia Begue Pastor, Anne E. Milner, Mark Drayson, John Gordon, and Alan B. Rickinson From the Cancer Research UK Institute for Cancer Studies and the MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham, United Kingdom. Immunoglobulin genotyping of Epstein-Barr virus (EBV)-positive posttransplantation lymphoproliferative disease has suggested that such lesions often arise from atypical post-germinal center B cells, in some cases carrying functionally inactivated immunoglobulin genes. To investigate whether EBV can rescue cells that are failed products of the somatic hypermutation process occurring in germinal centers (GCs), we isolated GC cells from tonsillar cell suspensions and exposed them to EBV in vitro. Screening more than 100 EBV-transformed cell lines of GC origin identified 6 lines lacking surface immunoglobulin, a phenotype never seen among lines derived from circulating naive or memory B cells. Furthermore, 3 of the 6 surface immunoglobulin-negative GC lines carried inactivating mutations in the immunoglobulin H (IgH) variable gene sequence. The ability of EBV to rescue aberrant products of the germinal center reaction in vitro strengthens the probability that a parallel activity contributes to EBV's lymphomagenic potential in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: EBV meets BCR- B cells Daniel Re Blood 2005 106: 4020-4021. 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