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 Blood, 15 December 2005, Vol. 106, No. 13, pp. 4377-4380.
Prepublished online as a Blood First Edition Paper on August 23, 2005; DOI 10.1182/blood-2005-06-2551.

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TRANSPLANTATION

First report of donor cell–derived acute leukemia as a complication of umbilical cord blood transplantation

Christopher J. Fraser, Betsy A. Hirsch, Vanessa Dayton, Michael H. Creer, Joseph P. Neglia, John E. Wagner, and K. Scott Baker

From the Department of Pediatrics, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Minnesota; the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN; and the Departments of Pathology and Pediatrics, St Louis University, St Louis, MO.

Donor cell leukemia is a rare complication after allogeneic hematopoietic stem cell transplantation. A 12-month-old boy underwent unrelated donor umbilical cord blood transplant (UCBT) for refractory Langerhan's cell histiocytosis. Forty months after transplantation, he developed acute myeloid leukemia. Cytogenetic and molecular analysis confirmed donor cell origin. The Cord Blood Bank (CBB) contacted the donor's family and established that the child, now 7 years old, was healthy. This represents the first reported case of donor cell leukemia following UCBT. This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients.


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C. M. Flynn and D. S. Kaufman
Donor cell leukemia: insight into cancer stem cells and the stem cell niche
Blood, April 1, 2007; 109(7): 2688 - 2692.
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