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Blood, 15 July 2005, Vol. 106, No. 2, pp. 740-745. Prepublished online as a Blood First Edition Paper on March 24, 2005; DOI 10.1182/blood-2005-02-0713. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-02-0713v1 106/2/740    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Beutler, E. Articles by West, C. Search for Related Content PubMed PubMed Citation Articles by Beutler, E. Articles by West, C. Related Collections Clinical Trials and Observations Red Cells Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS Hematologic differences between African-Americans and whites: the roles of iron deficiency and -thalassemia on hemoglobin levels and mean corpuscular volume Ernest Beutler, and Carol West From the Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA. The average results of some laboratory measurements, including the hemoglobin, mean corpuscular volume (MCV), serum transferrin saturation (TS), serum ferritin, and white blood cell count of African-Americans differ from those of whites. Anonymized samples and laboratory data from 1491 African-American and 31 005 white subjects, approximately equally divided between men and women, were analyzed. The hematocrit, hemoglobin, MCV, TS, and white blood cell counts of African-Americans were lower than those of whites; serum ferritin levels were higher. When iron-deficient patients were eliminated from consideration the differences in hematocrit, hemoglobin, and MCV among women were slightly less. The -3.7-kilobase -thalassemia deletion accounted for about one third of the difference in the hemoglobin levels of African-Americans and whites and neither sickle trait nor elevated creatinine levels had an effect. Among all subjects, 19.8% of African-American women would have been classified as "anemic" compared with 5.3% of whites. Among men, the figures were 17.7% and 7.6%. Without iron-deficient or thalassemic subjects, the difference had narrowed to 6.1% and 2.77% and to 4.29% and 3.6%, respectively. Physicians need to take into account that the same reference standards for hemoglobin, hematocrit, MCV, and TS and the white blood cell count do not apply to all ethnic groups. (Blood. 2005;106:740-745) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Hemoglobin levels in African-Americans Geraldine P. Schechter and Ernest Beutler Blood 2006 107: 2208-2209. [Full Text] [PDF] This article has been cited by other articles: B. N. Polite, C. Cirrincione, G. F. Fleming, D. A. Berry, A. Seidman, H. Muss, L. Norton, C. Shapiro, K. Bakri, K. Marcom, et al. Racial Differences in Clinical Outcomes From Metastatic Breast Cancer: A Pooled Analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B J. Clin. Oncol., June 1, 2008; 26(16): 2659 - 2665. [Abstract] [Full Text] [PDF] A. Artz and X. Dong Defining anemia by race using epidemiologic data Blood, March 1, 2008; 111(5): 2941 - 2941. [Full Text] [PDF] K. V. Patel, T. B. Harris, A. B. Newman, and J. M. Guralnik Further epidemiologic research on anemia in older adults is needed Blood, March 1, 2008; 111(5): 2941 - 2942. [Full Text] [PDF] G. B. 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Jeffreys Inaugural Article: Processes of copy-number change in human DNA: The dynamics of {alpha}-globin gene deletion PNAS, June 13, 2006; 103(24): 8921 - 8927. [Abstract] [Full Text] [PDF] G. P. Schechter and E. Beutler Hemoglobin levels in African-Americans. Blood, March 1, 2006; 107(5): 2208 - 2209. [Full Text] [PDF] E. Beutler and J. Waalen The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood, March 1, 2006; 107(5): 1747 - 1750. [Abstract] [Full Text] [PDF] V. M. Cardenas, Z. D. Mulla, M. Ortiz, and D. Y. Graham Iron Deficiency and Helicobacter pylori Infection in the United States Am. J. Epidemiol., January 15, 2006; 163(2): 127 - 134. [Abstract] [Full Text] [PDF] S. L. Schrier Hematology, ASH, and the anemia of the aged Blood, November 15, 2005; 106(10): 3341 - 3342. [Full Text] [PDF]

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