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Blood, 1 August 2005, Vol. 106, No. 3, pp. 1037-1041.
Prepublished online as a Blood First Edition Paper on April 21, 2005; DOI 10.1182/blood-2005-01-0004.
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NEOPLASIA
Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori–independent status of low-grade gastric mucosa–associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21)
Kun-Huei Yeh,
Sung-Hsin Kuo,
Li-Tzong Chen,
Tsui-Lien Mao,
Shin-Lian Doong,
Ming-Shiang Wu,
Hui-Chen Hsu,
Yi-Shin Tzeng,
Chi-Long Chen,
Jaw-Town Lin, and
Ann-Lii Cheng
From the Departments of Oncology, Internal Medicine, and Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei; Cancer Research Center, Graduate Institute of Clinical Medicine, and Graduate Institute of Microbiology, National Taiwan University College of Medicine, Taipei; Division of Cancer Research, National Health Research Institutes, Taipei; Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung; Department of Pathology, Taipei Medical University, Taipei; and Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.
The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori–independent status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF- B) was recently found to be closely associated with H pylori–independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these 2 markers can also predict H pylori–independent status of low-grade gastric MALT lymphomas without t(11; 18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3%) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6%) were H pylori dependent and 11 (23.4%) were H pylori independent. Nuclear expression of BCL10 was significantly higher in H pylori–independent than in H pylori–dependent tumors (8 of 11 [72.7%] vs 3 of 36 [8.3%]; P < .001). Nuclear expression of NF-B was also significantly higher in H pylori–independent than in H pylori–dependent tumors (7 of 11 [63.6%] vs 3 of 36 [8.3%]; P < .001). Further, nuclear translocation of BCL10 and NF-B was observed in 12 of the 13 patients with t(11;18)(q21;q21), and all these 12 patients were H pylori independent. In summary, nuclear expression of BCL10 or NF-B is predictive of H pylori–independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21).
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