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Blood, 1 August 2005, Vol. 106, No. 3, pp. 1063-1066. Prepublished online as a Blood First Edition Paper on April 19, 2005; DOI 10.1182/blood-2004-08-3225. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-08-3225v1 106/3/1063    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sujobert, P. Articles by Bouscary, D. Search for Related Content PubMed PubMed Citation Articles by Sujobert, P. Articles by Bouscary, D. Related Collections Neoplasia Signal Transduction Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief report Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia Pierre Sujobert, Valerie Bardet, Pascale Cornillet-Lefebvre, Joel S. Hayflick, Nolwen Prie, Frederic Verdier, Bart Vanhaesebroeck, Odile Muller, Florence Pesce, Norbert Ifrah, Mathilde Hunault-Berger, Christian Berthou, Bruno Villemagne, Eric Jourdan, Bruno Audhuy, Eric Solary, Brigitte Witz, Jean Luc Harousseau, Chantal Himberlin, Thierry Lamy, Bruno Lioure, Jean Yves Cahn, Francois Dreyfus, Patrick Mayeux, Catherine Lacombe, and Didier Bouscary From the Département d'Hématologie, INSERM U567, CNRS UMR 8104, Université Paris Descartes 5, Institut Cochin, and Service d'Hématologie and the Département de Statistique, Hôpital Cochin, AP-HP, Paris, France; Laboratoire d'Hématologie, Hôpital de Reims, Reims, France; ICOS Corporation, Bothell, Washington; Ludwig Institute for Cancer Research and the Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom; and Groupe Ouest-Est des Leucémies et des Autres Maladies du Sang (GOELAMS), Tours, France. The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway has been shown to be frequently activated in blast cells from patients with acute myeloid leukemia (AML) and to contribute to survival and proliferation of these cells. Of the 8 distinct mammalian isoforms of PI3K, it is the class I PI3Ks (p110, p110, p110, and p110) that are responsible for Akt activation. It is not known which PI3K isoform is critical in AML. Here we show that the p110 isoform of PI3K is consistently expressed at a high level in blast cells from AML, in contrast to the other class I isoforms, the expression of which was very variable among patients. IC87114, a p110-selective inhibitor, suppressed both constitutive and Flt-3–stimulated Akt activation in blasts to the same extent as Ly294002, an inhibitor of all PI3K isoforms. Moreover, IC87114 inhibited AML cell proliferation without affecting the proliferation of normal hematopoietic progenitor cells. These observations identify p110 as a potential therapeutic target in AML. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. R. Geest, F. J. Zwartkruis, E. Vellenga, P. J. Coffer, and M. Buitenhuis Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells Haematologica, July 1, 2009; 94(7): 901 - 910. [Abstract] [Full Text] [PDF] A. Saudemont, F. Garcon, H. Yadi, M. Roche-Molina, N. Kim, A. Segonds-Pichon, A. Martin-Fontecha, K. Okkenhaug, and F. Colucci p110{gamma} and p110{delta} isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease PNAS, April 7, 2009; 106(14): 5795 - 5800. [Abstract] [Full Text] [PDF] C. Billottet, L. Banerjee, B. Vanhaesebroeck, and A. 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