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Blood, 1 August 2005, Vol. 106, No. 3, pp. 899-902. Prepublished online as a Blood First Edition Paper on April 14, 2005; DOI 10.1182/blood-2005-02-0560. This Article Full Text Full Text (PDF) Supplemental Materials All Versions of this Article: 2005-02-0560v1 106/3/899    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Alcalay, M. Articles by Pelicci, P. G. Search for Related Content PubMed PubMed Citation Articles by Alcalay, M. Articles by Pelicci, P. G. Related Collections Hematopoiesis and Stem Cells Neoplasia Gene Expression Genomics Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Brief report Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance Myriam Alcalay, Enrico Tiacci, Roberta Bergomas, Barbara Bigerna, Elisa Venturini, Simone P. Minardi, Natalia Meani, Daniela Diverio, Loris Bernard, Laura Tizzoni, Sara Volorio, Lucilla Luzi, Emanuela Colombo, Francesco Lo Coco, Cristina Mecucci, Brunangelo Falini, Pier Giuseppe Pelicci, for the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Acute Leukemia Working Party From the Institute of Molecular Oncology (IFOM) of the Italian Foundation for Cancer Research, Milan, Italy; the European Institute of Oncology, Milan, Italy; the Institute of Hematology, University of Perugia, Perugia, Italy; the Institute of Hematology, University La Sapienza, Rome, Italy; and the Department of Biopathology, University of Tor Vergata, Rome, Italy. Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant cytoplasmic localization of nucleophosmin (NPMc+ AML), consequent to mutations in the NPM putative nucleolar localization signal. These events are mutually exclusive with the major AML-associated chromosomal rearrangements, and are frequently associated with normal karyotype, FLT3 mutations, and multilineage involvement. We report the gene expression profiles of 78 de novo AMLs (72 with normal karyotype; 6 without major chromosomal abnormalities) that were characterized for the subcellular localization and mutation status of NPM. Unsupervised clustering clearly separated NPMc+ from NPMc– AMLs, regardless of the presence of FLT3 mutations or non–major chromosomal rearrangements, supporting the concept that NPMc+ AML represents a distinct entity. The molecular signature of NPMc+ AML includes up-regulation of several genes putatively involved in the maintenance of a stem-cell phenotype, suggesting that NPMc+ AML may derive from a multipotent hematopoietic progenitor. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: U. Bacher, A. 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