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Blood, 1 August 2005, Vol. 106, No. 3, pp. 903-905. Prepublished online as a Blood First Edition Paper on April 14, 2005; DOI 10.1182/blood-2004-12-4960. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-12-4960v1 106/3/903    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kim, I. Articles by Morrison, S. J. Search for Related Content PubMed PubMed Citation Articles by Kim, I. Articles by Morrison, S. J. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Cell Adhesion and Motility Brief Reports Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Brief report CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells Injune Kim, Ömer H. Yilmaz, and Sean J. Morrison From the Howard Hughes Medical Institute, and the Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan, Ann Arbor, MI. Hematopoietic stem cells (HSCs) and endothelial progenitors arise from a common embryonic precursor. However, these populations diverge prior to the onset of definitive hematopoiesis, as HSCs become CD45+ and are thought to lose the expression of endothelial markers. After the onset of definitive hematopoiesis, CD144 (vascular endothelial [VE]–cadherin) has been considered a specific marker of endothelial cells. In contrast, we found that virtually all HSC activity from embryonic day 13.5 (E13.5) fetal liver was CD144+. CD144 expression declined on E16.5 fetal liver HSCs and was absent from adult bone marrow HSCs. This identified a new marker that is differentially expressed between fetal and adult HSCs, and enhanced the purification of HSCs from the E13.5 fetal liver. These results emphasize the close developmental relationship between hematopoietic and endothelial cells, while indicating that CD144 is not a specific marker of endothelial cells during fetal development. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Endothelial cell–specific markers: going... going... gone William H. Fleming Blood 2005 106: 769. 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