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Blood, 15 August 2005, Vol. 106, No. 4, pp. 1441-1446. Prepublished online as a Blood First Edition Paper on May 3, 2005; DOI 10.1182/blood-2004-12-4782. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-12-4782v1 106/4/1441    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cook, J. D. Articles by del Carmen Daroca, M. Search for Related Content PubMed PubMed Citation Articles by Cook, J. D. Articles by del Carmen Daroca, M. Related Collections Red Cells Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS The influence of high-altitude living on body iron James D. Cook, Erick Boy, Carol Flowers, and Maria del Carmen Daroca From the Department of Medicine, Kansas University Medical Center, Kansas City, KS; The Micronutrient Initiative, Ottawa, ON, Canada; and Pan American Health Organisation, La Paz, Bolivia. The quantitative assessment of body iron based on measurements of the serum ferritin and transferrin receptor was used to examine iron status in 800 Bolivian mothers and one of their children younger than 5 years. The survey included populations living at altitudes between 156 to 3750 m. Body iron stores in the mothers averaged 3.88 ± 4.31 mg/kg (mean ± 1 SD) and 1.72 ± 4.53 mg/kg in children. No consistent effect of altitude on body iron was detected in children but body iron stores of 2.77 ± 0.70 mg/kg (mean ± 2 standard error [SE]) in women living above 3000 m was reduced by one-third compared with women living at lower altitudes (P < .001). One half of the children younger than 2 years were iron deficient, but iron stores then increased linearly to approach values in their mothers by 4 years of age. When body iron in mothers was compared with that of their children, a striking correlation was observed over the entire spectrum of maternal iron status (r = 0.61, P < .001). This finding could provide the strongest evidence to date of the importance of dietary iron as a determinant of iron status in vulnerable segments of a population. (Blood. 2005;106:1441-1446) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Iron and high living Chaim Hershko Blood 2005 106: 1142. [Full Text] [PDF] This article has been cited by other articles: M. E Cogswell, A. C Looker, C. M Pfeiffer, J. D Cook, D. A Lacher, J. L Beard, S. R Lynch, and L. M Grummer-Strawn Assessment of iron deficiency in US preschool children and nonpregnant females of childbearing age: National Health and Nutrition Examination Survey 2003-2006 Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1334 - 1342. [Abstract] [Full Text] [PDF] R. C Tasker Oxygen and living at altitude Arch. Dis. Child., January 1, 2009; 94(1): 1 - 2. [Full Text] [PDF] M. Wijaya-Erhardt, J. G Erhardt, J. Untoro, E. Karyadi, L. Wibowo, and R. Gross Effect of daily or weekly multiple-micronutrient and iron foodlike tablets on body iron stores of Indonesian infants aged 6 12 mo: a double-blind, randomized, placebo-controlled trial Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1680 - 1686. [Abstract] [Full Text] [PDF] J. L Beard, L. E Murray-Kolb, F. J Rosales, N. W Solomons, and M. L. Angelilli Interpretation of serum ferritin concentrations as indicators of total-body iron stores in survey populations: the role of biomarkers for the acute phase response Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1498 - 1505. [Abstract] [Full Text] [PDF]

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