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Blood, 15 August 2005, Vol. 106, No. 4, pp. 1460-1465. Prepublished online as a Blood First Edition Paper on April 28, 2005; DOI 10.1182/blood-2004-10-3982. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-10-3982v1 106/4/1460    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wood, J. C. Articles by Coates, T. D. Search for Related Content PubMed PubMed Citation Articles by Wood, J. C. Articles by Coates, T. D. Related Collections Red Cells Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  RED CELLS MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients John C. Wood, Cathleen Enriquez, Nilesh Ghugre, J. Michael Tyzka, Susan Carson, Marvin D. Nelson, and Thomas D. Coates From the Department of Pediatrics and the Department of Radiology, Children's Hospital of Los Angeles, CA; and the Department of Biology, California Institute of Technology, Pasadena, CA. Measurements of hepatic iron concentration (HIC) are important predictors of transfusional iron burden and long-term outcome in patients with transfusion-dependent anemias. The goal of this work was to develop a readily available, noninvasive method for clinical HIC measurement. The relaxation rates R2 (1/T2) and R2* (1/T2*) measured by magnetic resonance imaging (MRI) have different advantages for HIC estimation. This article compares noninvasive iron estimates using both optimized R2 and R2* methods in 102 patients with iron overload and 13 controls. In the iron-overloaded group, 22 patients had concurrent liver biopsy. R2 and R2* correlated closely with HIC (r2 .95) for HICs between 1.33 and 32.9 mg/g, but R2 had a curvilinear relationship to HIC. Of importance, the R2 calibration curve was similar to the curve generated by other researchers, despite significant differences in technique and instrumentation. Combined R2 and R2* measurements did not yield more accurate results than either alone. Both R2 and R2* can accurately measure hepatic iron concentration throughout the clinically relevant range of HIC with appropriate MRI acquisition techniques. 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