|
|
Blood, 1 September 2005, Vol. 106, No. 5, pp. 1867-1874.
Prepublished online as a Blood First Edition Paper on May 12, 2005; DOI 10.1182/blood-2005-02-0468.
Previous Article | Table of Contents | Next Article 
TRANSPLANTATION
The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
Neal Flomenberg,
Steven M. Devine,
John F. DiPersio,
Jane L. Liesveld,
John M. McCarty,
Scott D. Rowley,
David H. Vesole,
Karin Badel, and
Gary Calandra
From the Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA; the Department of Medicine and Siteman Cancer Center, Washington University, St Louis, MO; the Department of Medicine and James P. Wilmot Cancer Center, University of Rochester, Rochester, NY; the Department of Medicine and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA; the Adult Blood and Marrow Transplantation Program, Hackensack University Medical Center, Hackensack, NJ; the Medical College of Wisconsin, Milwaukee, WI; and AnorMED, Langley, BC, Canada.
Hematopoietic progenitor cells (HPCs) traffic to and are retained in the marrow through the trophic effects of the chemokine stromal cell-derived factor-1 (SDF-1 ) binding to its receptor, CXC chemokine receptor 4 (CXCR4). AMD3100 reversibly inhibits SDF-1 /CXCR4 binding, and AMD3100 administration mobilizes CD34+ cells into the circulation. We therefore tested the hypotheses that the combination of AMD3100 plus granulocyte colony-stimulating factor (G-CSF) (hereafter A + G) would be superior to G-CSF alone (hereafter G) in mobilizing hematopoietic progenitor cells (HPCs) and that A + G-mobilized cells would engraft as well as G-mobilized cells. The primary objective was to determine whether patients mobilized more progenitor cells per unit of blood volume of apheresis after A + G administration versus G alone. Secondary objectives were to determine whether patients mobilized with A + G compared with G alone required fewer apheresis procedures to reach the target level at least 5 x 106 CD34+ cells/kg for transplantation and to determine whether patients mobilized with A + G had at least a 90% success rate of autologous transplantation as assessed by neutrophil engraftment by day 21. Each patient served as his or her own control in a sequential mobilization design. All study objectives were met without significant toxicity. The results demonstrate that the combination of A + G is generally safe, effective, and superior to G alone for autologous HPC mobilization. (Blood. 2005;106:1867-1874)

CiteULike Connotea Del.icio.us Digg Reddit Technorati What's this?
Related Article in Blood Online:
-
Progenitor cell mobilization gets a boost from CXCR4 inhibition
- Susan F. Leitman
Blood 2005 106: 1516-1517.
[Full Text]
[PDF]
This article has been cited by other articles:

|
 |

|
 |
 
A. Y. H. Leung and Y.-L. Kwong
Haematopoietic stem cell transplantation: current concepts and novel therapeutic strategies
Br. Med. Bull.,
November 8, 2009;
(2009)
ldp040v1.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. F. DiPersio, I. N. Micallef, P. J. Stiff, B. J. Bolwell, R. T. Maziarz, E. Jacobsen, A. Nademanee, J. McCarty, G. Bridger, and G. Calandra
Phase III Prospective Randomized Double-Blind Placebo-Controlled Trial of Plerixafor Plus Granulocyte Colony-Stimulating Factor Compared With Placebo Plus Granulocyte Colony-Stimulating Factor for Autologous Stem-Cell Mobilization and Transplantation for Patients With Non-Hodgkin's Lymphoma
J. Clin. Oncol.,
October 1, 2009;
27(28):
4767 - 4773.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. E. Donahue, P. Jin, A. C. Bonifacino, M. E. Metzger, J. Ren, E. Wang, and D. F. Stroncek
Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures
Blood,
September 17, 2009;
114(12):
2530 - 2541.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. K. Azab and I. M. Ghobrial
Response: Sensitization initiated
Blood,
July 23, 2009;
114(4):
926 - 927.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Z. Zeng, Y. Xi Shi, I. J. Samudio, R.-Y. Wang, X. Ling, O. Frolova, M. Levis, J. B. Rubin, R. R. Negrin, E. H. Estey, et al.
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
Blood,
June 11, 2009;
113(24):
6215 - 6224.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Nervi, P. Ramirez, M. P. Rettig, G. L. Uy, M. S. Holt, J. K. Ritchey, J. L. Prior, D. Piwnica-Worms, G. Bridger, T. J. Ley, et al.
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
Blood,
June 11, 2009;
113(24):
6206 - 6214.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. K. Azab, J. M. Runnels, C. Pitsillides, A.-S. Moreau, F. Azab, X. Leleu, X. Jia, R. Wright, B. Ospina, A. L. Carlson, et al.
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
Blood,
April 30, 2009;
113(18):
4341 - 4351.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. A. Schroeder, M. P. Rettig, P. Ramirez, and J. F. DiPersio
Optimal Mobilization of Normal and Leukemic Stem Cells via Modulation of Chemokine and Integrin Axes
Am. Assoc. Cancer Res. Educ. Book,
April 18, 2009;
2009(1):
15 - 22.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. S. Y. Wong, V. Bodart, M. Metz, J. Labrecque, G. Bridger, and S. P. Fricker
Comparison of the Potential Multiple Binding Modes of Bicyclam, Monocylam, and Noncyclam Small-Molecule CXC Chemokine Receptor 4 Inhibitors
Mol. Pharmacol.,
December 1, 2008;
74(6):
1485 - 1495.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. M. Devine, R. Vij, M. Rettig, L. Todt, K. McGlauchlen, N. Fisher, H. Devine, D. C. Link, G. Calandra, G. Bridger, et al.
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction
Blood,
August 15, 2008;
112(4):
990 - 998.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. M. Lazarus, G. L. Phillips, R. H. Herzig, D. D. Hurd, S. N. Wolff, and G. P. Herzig
High-Dose Melphalan and the Development of Hematopoietic Stem-Cell Transplantation: 25 Years Later
J. Clin. Oncol.,
May 10, 2008;
26(14):
2240 - 2243.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. M. Lemoli and A. D'Addio
Hematopoietic stem cell mobilization
Haematologica,
March 1, 2008;
93(3):
321 - 324.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Zernecke, I. Bot, Y. Djalali-Talab, E. Shagdarsuren, K. Bidzhekov, S. Meiler, R. Krohn, A. Schober, M. Sperandio, O. Soehnlein, et al.
Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis
Circ. Res.,
February 1, 2008;
102(2):
209 - 217.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Lowenberg
Acute Myeloid Leukemia: The Challenge of Capturing Disease Variety
Hematology,
January 1, 2008;
2008(1):
1 - 11.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. F. Wolff, A. B. Wolff, Hongling Du, and H. S. Taylor
Demonstration of Multipotent Stem Cells in the Adult Human Endometrium by In Vitro Chondrogenesis
Reproductive Sciences,
September 1, 2007;
14(6):
524 - 533.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
M Devetten and J. Armitage
Hematopoietic cell transplantation: progress and obstacles
Ann. Onc.,
September 1, 2007;
18(9):
1450 - 1456.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. C. Hirbe, J. Rubin, O. Uluckan, E. A. Morgan, M. C. Eagleton, J. L. Prior, D. Piwnica-Worms, and K. N. Weilbaecher
Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone
PNAS,
August 28, 2007;
104(35):
14062 - 14067.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Shiba, M. Takahashi, T. Yoshioka, N. Yajima, H. Morimoto, A. Izawa, H. Ise, K. Hatake, K. Motoyoshi, and U. Ikeda
M-CSF Accelerates Neointimal Formation in the Early Phase After Vascular Injury in Mice: The Critical Role of the SDF-1-CXCR4 System
Arterioscler Thromb Vasc Biol,
February 1, 2007;
27(2):
283 - 289.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Kawai, U. Choi, L. Cardwell, S. S. DeRavin, N. Naumann, N. L. Whiting-Theobald, G. F. Linton, J. Moon, P. M. Murphy, and H. L. Malech
WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4
Blood,
January 1, 2007;
109(1):
78 - 84.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Z. Zeng, I. J. Samudio, M. Munsell, J. An, Z. Huang, E. Estey, M. Andreeff, and M. Konopleva
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
Mol. Cancer Ther.,
December 1, 2006;
5(12):
3113 - 3121.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. F. Cashen, G. Calandra, R. MacFarland, S. Lopez, and J. F. DiPersio
A Mobilizing Regimen of AMD3100 and G-CSF Increases Stem Cell Collection in Patients with Hodgkin's Disease, and PK Is Similar to That of Non-Cancer Patients.
Blood (ASH Annual Meeting Abstracts),
November 16, 2006;
108(11):
3053 - 3053.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Larochelle, A. Krouse, M. Metzger, D. Orlic, R. E. Donahue, S. Fricker, G. Bridger, C. E. Dunbar, and P. Hematti
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates
Blood,
May 1, 2006;
107(9):
3772 - 3778.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Chen, A. Larochelle, S. Fricker, G. Bridger, C. E. Dunbar, and J. L. Abkowitz
Mobilization as a preparative regimen for hematopoietic stem cell transplantation
Blood,
May 1, 2006;
107(9):
3764 - 3771.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. A. Copelan
Hematopoietic stem-cell transplantation.
N. Engl. J. Med.,
April 27, 2006;
354(17):
1813 - 1826.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. M. Devine
Antagonizing CXCR4 accelerates CD34+ cell mobilization
Blood,
December 1, 2005;
106(12):
3685 - 3686.
[Full Text]
[PDF]
|
 |
|
|
|