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Blood, 15 September 2005, Vol. 106, No. 6, pp. 2033-2041. Prepublished online as a Blood First Edition Paper on June 7, 2005; DOI 10.1182/blood-2004-12-4831. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-12-4831v1 106/6/2033    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Guo, Z. Articles by Cao, X. Search for Related Content PubMed PubMed Citation Articles by Guo, Z. Articles by Cao, X. 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We previously reported that Fas ligation induced interleukin 1 (IL-1)–dependent maturation and IL-1–independent survival of DCs, with extracellular signal–regulated kinase (ERK) and nuclear factor–B (NF-B) signaling pathways involved, respectively. We describe here that Fas ligation induced DCs to rapidly produce both CXC and CC chemokines, including macrophage inflammatory protein 2 (MIP-2), MIP-1, MIP-1, monocyte chemoattractant protein 1 (MCP-1), RANTES (regulated on activation normal T cell expressed and secreted), and TARC (thymus and activation-regulated chemokine), resulting in enhanced chemoattraction of neutrophils and T cells by Fas-ligated DCs in vivo or by its supernatant in vitro. These chemokines work synergistically in chemoattraction of neutrophils and T cells with MIP-2 more important for neutrophils, MIP-1 and TARC more important for T cells. Moreover, Fas-ligated DCs increased endocytosis by neutrophils and activation and proliferation of antigen-specific naive T cells. Fas ligation-induced DC secretion of chemokines involves Ras/Raf/mitogen-activated protein kinase kinase (MEK)/ERK activation and is ERK, but not NF-B, dependent. Activation of caspases, including caspase 1, but not IL-1 autocrine action, is involved in this process. These data indicate that Fas signaling provides a key link between innate response and adaptive immunity by promoting DC chemokine production. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Rethi, N. Vivar, S. Sammicheli, C. Fluur, N. Ruffin, A. Atlas, E. Rajnavolgyi, and F. Chiodi Priming of T cells to Fas-mediated proliferative signals by interleukin-7 Blood, August 15, 2008; 112(4): 1195 - 1204. [Abstract] [Full Text] [PDF] G. Plitas, B. M. Burt, H. M. Nguyen, Z. M. Bamboat, and R. P. 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