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Blood, 15 September 2005, Vol. 106, No. 6, pp. 2091-2098. Prepublished online as a Blood First Edition Paper on June 9, 2005; DOI 10.1182/blood-2005-02-0449. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-02-0449v1 106/6/2091    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by van Leeuwen, E. M. M. Articles by van Lier, R. A. W. Search for Related Content PubMed PubMed Citation Articles by van Leeuwen, E. M. M. Articles by van Lier, R. A. W. Related Collections Immunobiology Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY IL-7 receptor chain expression distinguishes functional subsets of virus-specific human CD8+ T cells Ester M. M. van Leeuwen, Godelieve J. de Bree, Ester B. M. Remmerswaal, Si-La Yong, Kiki Tesselaar, Ineke J. M. ten Berge, and René A. W. van Lier From the Department of Experimental Immunology, the Department of Internal Medicine, Divisions of Nephrology and Clinical Immunology and Rheumatology, and the Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands; and the Department of Clinical Viro-Immunology, Sanquin Research at CLB, Amsterdam, The Netherlands. Virus-specific CD8+ T cells emerge after infection with herpesviruses and maintain latency to these persistent pathogens. It has been demonstrated that murine memory CD8+ T-cell precursors specific for acute lymphocytic choriomeningitis virus express interleukin-7 receptor (IL-7R), and IL-7 is involved in maintaining memory populations after the clearance of antigen. To investigate whether human CD8+ T cells reactive toward persistent viruses are maintained similarly, we analyzed IL-7R expression and function on these virus-specific cells. During primary infection, all cytomegalovirus (CMV)-specific CD8+ T cells and most Epstein-Barr virus (EBV)-specific CD8+ T cells lacked IL-7R expression. Only some virus-specific T cells expressed IL-7R late after viral replication became undetectable. CD8+ T cells specific for cleared viruses, influenza (FLU), and respiratory syncytial virus (RSV) all expressed IL-7R. Remarkably, the percentage of IL-7R- CMV-specific T cells correlated with the height of viral replication in the acute phase. Virus-specific IL-7R+ cells proliferated vigorously in response to IL-7, IL-15, or peptide, whereas IL-7R- cells required both peptide and helper-cell activation or IL-2 or IL-15 for optimal expansion. Our data suggest that although IL-7 is essential for the maintenance of memory cells in the absence of antigen, CD8+ T cells specific for latent viruses need T-cell receptor activation plus helper factors to persist. (Blood. 2005;106:2091-2098) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. L. Alves, E. M. M. van Leeuwen, I. A. M. Derks, and R. A. W. van Lier Differential Regulation of Human IL-7 Receptor {alpha} Expression by IL-7 and TCR Signaling J. Immunol., April 15, 2008; 180(8): 5201 - 5210. [Abstract] [Full Text] [PDF] M. Rehr, J. Cahenzli, A. Haas, D. A. Price, E. Gostick, M. Huber, U. Karrer, and A. 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