Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
Blood, 15 September 2005, Vol. 106, No. 6, pp. 2102-2104.
Prepublished online as a Blood First Edition Paper on June 2, 2005; DOI 10.1182/blood-2005-03-0874.


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2005-03-0874v1
106/6/2102    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Führer, M.
Right arrow Articles by Bender-Goetze, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Führer, M.
Right arrow Articles by Bender-Goetze, C.
Related Collections
Right arrow Immunobiology
Right arrow Red Cells
Right arrow Brief Reports
Right arrow Clinical Trials and Observations
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

IMMUNOBIOLOGY
Brief report

Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival

Monika Führer, Udo Rampf, Irith Baumann, Andreas Faldum, Charlotte Niemeyer, Gritta Janka-Schaub, Wilhelm Friedrich, Wolfram Ebell, Arndt Borkhardt, Christine Bender-Goetze, for the German/Austrian Aplastic Anemia Working Group

From the Children's University Hospital, Department of Hematology and Oncology, Ludwig-Maximilians-University, Munich, Germany; the Department of Pathology, University of Erlangen, Erlangen, Germany; the Institut for Medizinische Biometrie, Epidemiologie und Informatik, Johannes Gutenberg University, Mainz, Germany; the Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany; the Children's University Hospital, Department of Hematology and Oncology, Hamburg, Germany; the Department of Pediatrics, University of Ulm, Ulm, Germany; and the Department of Pediatrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany.

Severe acquired aplastic anaemia (SAA) is a life-threatening disease characterized by pancytopenia and hypoplastic bone marrow. Autologous T lymphocytes are thought to cause bone marrow failure by immune-mediated excessive apoptosis of stem and progenitor cells. The disease is subclassified into a severe (neutrophil count, > 0.2 x 109/L [> 200/µL]) and a very severe (< 0.2 x 109/L [< 200/µL]) (vSAA) form. We report the results of a prospective multicenter trial with a combined immunosuppressive regimen of cyclosporin A (CSA), anti-thymocyte globulin (ATG) and, in cases with neutrophil counts fewer than 0.5 x 109/L (< 500/µL), granulocyte colony-stimulating factor (G-CSF) for treatment of SAA in children. Children with vSAA showed a higher rate of complete response than did children with SAA (68% versus 45%; P = .009), as well as better survival (93% versus 81%; P < .001). Thus, in children with SAA a more severe disease stage at diagnosis indicates a favorable outcome with immunosuppressive therapy. (Blood. 2005;106:2102-2104)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
haematolHome page
R. Gurion, A. Gafter-Gvili, M. Paul, L. Vidal, I. Ben-Bassat, M. Yeshurun, O. Shpilberg, and P. Raanani
Hematopoietic growth factors in aplastic anemia patients treated with immunosuppressive therapy-systematic review and meta-analysis
Haematologica, May 1, 2009; 94(5): 712 - 719.
[Abstract] [Full Text] [PDF]


Home page
haematolHome page
J. R. Passweg and A. Tichelli
Immunosuppressive treatment for aplastic anemia: are we hitting the ceiling?
Haematologica, March 1, 2009; 94(3): 310 - 312.
[Full Text] [PDF]


Home page
haematolHome page
P. Scheinberg, C. O. Wu, O. Nunez, P. Scheinberg, C. Boss, E. M. Sloand, and N. S. Young
Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study
Haematologica, March 1, 2009; 94(3): 348 - 354.
[Abstract] [Full Text] [PDF]


Home page
haematolHome page
A. Yoshimi, I. Baumann, M. Fuhrer, E. Bergstrasser, U. Gobel, K.-W. Sykora, T. Klingebiel, U. Gross-Wieltsch, M. M van den Heuvel-Eibrink, A. Fischer, et al.
Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia
Haematologica, March 1, 2007; 92(3): 397 - 400.
[Abstract] [Full Text] [PDF]


Home page
haematolHome page
J. C.W. Marsh
Treatment of acquired aplastic anemia
Haematologica, January 1, 2007; 92(1): 2 - 5.
[Full Text] [PDF]


Home page
haematolHome page
A. Locasciulli, R. Oneto, A. Bacigalupo, G. Socie, E. Korthof, A. Bekassy, H. Schrezenmeier, J. Passweg, M. Fuhrer, and on the behalf of the Severe Aplastic Anemia Workin
Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation
Haematologica, January 1, 2007; 92(1): 11 - 18.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
N. S. Young, R. T. Calado, and P. Scheinberg
Current concepts in the pathophysiology and treatment of aplastic anemia
Blood, October 15, 2006; 108(8): 2509 - 2519.
[Abstract] [Full Text] [PDF]


Home page
ASH Education BookHome page
E. C. Guinan
Aplastic Anemia: Management of Pediatric Patients
Hematology, January 1, 2005; 2005(1): 104 - 109.
[Abstract] [Full Text] [PDF]



 click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020