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Blood, 15 September 2005, Vol. 106, No. 6, pp. 2138-2146. Prepublished online as a Blood First Edition Paper on June 2, 2005; DOI 10.1182/blood-2005-02-0471. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-02-0471v1 106/6/2138    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Baumforth, K. R. N. Articles by Murray, P. G. Search for Related Content PubMed PubMed Citation Articles by Baumforth, K. R. N. Articles by Murray, P. G. Related Collections Neoplasia Signal Transduction Free Research Articles Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells Karl R. N. Baumforth, Joanne R. Flavell, Gary M. Reynolds, Gillian Davies, Trevor R. Pettit, Wenbin Wei, Susan Morgan, Tanya Stankovic, Yasuhiro Kishi, Hiroyuki Arai, Marketa Nowakova, Guy Pratt, Junken Aoki, Michael J. O. Wakelam, Lawrence S. Young, and Paul G. Murray From the Cancer Research UK (CRUK) Institute for Cancer Studies and Liver Research Laboratories, University of Birmingham, Birmingham, West Midlands, United Kingdom; and the Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan. A proportion of patients with Hodgkin lymphoma carry Epstein-Barr virus (EBV), an oncogenic herpesvirus, in their tumor cells. Although it is generally assumed that EBV contributes to the malignant phenotype of Hodgkin lymphoma cells, direct evidence in support of this is lacking. Here we show that EBV infection of Hodgkin lymphoma cells results in the induction of autotaxin, a secreted tumor-associated factor with lysophospholipase-D activity. Up-regulation of autotaxin increased the generation of lysophosphatidic acid (LPA) and led to the enhanced growth and survival of Hodgkin lymphoma cells, whereas specific down-regulation of autotaxin decreased LPA levels and reduced cell growth and viability. In lymphoma tissues, autotaxin expression was mainly restricted to CD30+ anaplastic large-cell lymphomas and Hodgkin lymphoma; in the latter, high levels of autotaxin were strongly associated with EBV positivity (P = .006). Our results identify the induction of autotaxin and the subsequent generation of LPA as key molecular events that mediate the EBV-induced growth and survival of Hodgkin lymphoma cells and suggest that this pathway may provide opportunities for novel therapeutic intervention. (Blood. 2005;106:2138-2146) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: LPA signaling stimulates Hodgkin research Gerald Niedobitek Blood 2005 106: 1898-1899. [Full Text] [PDF] This article has been cited by other articles: K. R.N. Baumforth, A. Birgersdotter, G. M. Reynolds, W. Wei, G. Kapatai, J. R. Flavell, E. Kalk, K. Piper, S. Lee, L. Machado, et al. Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells Am. J. Pathol., July 1, 2008; 173(1): 195 - 204. [Abstract] [Full Text] [PDF] J. R. Flavell, K. R. N. Baumforth, V. H. J. Wood, G. L. Davies, W. Wei, G. M. Reynolds, S. Morgan, A. Boyce, G. L. Kelly, L. S. Young, et al. Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells Blood, January 1, 2008; 111(1): 292 - 301. [Abstract] [Full Text] [PDF] G Kapatai and P Murray Contribution of the Epstein Barr virus to the molecular pathogenesis of Hodgkin lymphoma J. Clin. Pathol., December 1, 2007; 60(12): 1342 - 1349. [Abstract] [Full Text] [PDF] J.-H. Lin, C.-H. Tsai, J.-S. Chu, J.-Y. Chen, K. Takada, and J.-Y. Shew Dysregulation of HER2/HER3 Signaling Axis in Epstein-Barr Virus-Infected Breast Carcinoma Cells J. Virol., June 1, 2007; 81(11): 5705 - 5713. [Abstract] [Full Text] [PDF] S. Jansen, N. Callewaert, I. Dewerte, M. Andries, H. Ceulemans, and M. Bollen An Essential Oligomannosidic Glycan Chain in the Catalytic Domain of Autotaxin, a Secreted Lysophospholipase-D J. Biol. Chem., April 13, 2007; 282(15): 11084 - 11091. [Abstract] [Full Text] [PDF] M. Tanaka, S. Okudaira, Y. Kishi, R. Ohkawa, S. Iseki, M. Ota, S. Noji, Y. Yatomi, J. Aoki, and H. Arai Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid J. Biol. Chem., September 1, 2006; 281(35): 25822 - 25830. [Abstract] [Full Text] [PDF] L. A. van Meeteren, P. Ruurs, C. Stortelers, P. Bouwman, M. A. van Rooijen, J. P. Pradere, T. R. Pettit, M. J. O. Wakelam, J. S. Saulnier-Blache, C. L. Mummery, et al. Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development. Mol. Cell. Biol., July 1, 2006; 26(13): 5015 - 5022. [Abstract] [Full Text] [PDF] T. R. Pettitt, S. K. Dove, A. Lubben, S. D. J. Calaminus, and M. J. O. Wakelam Analysis of intact phosphoinositides in biological samples J. Lipid Res., July 1, 2006; 47(7): 1588 - 1596. [Abstract] [Full Text] [PDF]

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