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Blood, 1 October 2005, Vol. 106, No. 7, pp. 2252-2258.
Prepublished online as a Blood First Edition Paper on June 2, 2005; DOI 10.1182/blood-2005-03-1154.
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REVIEW ARTICLES
Natural-killer cells and dendritic cells: "l'union fait la force"
Thierry Walzer,
Marc Dalod,
Scott H. Robbins,
Laurence Zitvogel, and
Eric Vivier
From the Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique (INSERM-CNRS) Université Méditerranée, Campus de Luminy, Marseille, France; and Department of Clinical Biology, Equipe de recherche mixte 0208, INSERM, Institut Gustave Roussy, Villejuif, France.
Several recent publications have focused on the newly described interactions between natural-killer (NK) cells and dendritic cells (DCs). Activated NK cells induce DC maturation either directly or in synergy with suboptimal levels of microbial signals. Immature DCs appear susceptible to autologous NK-cell-mediated cytolysis while mature DCs are protected. NK-cell-induced DC activation is dependent on both tumor necrosis factor- (TNF- )/interferon- (IFN- ) secretion and a cell-cell contact involving NKp30. In vitro, interleukin-12 (IL-12)/IL-18, IL-15, and IFN- / production by activated DCs enhance, in turn, NK-cell IFN- production, proliferation, and cytotoxic potential, respectively. In vivo, NK-cell/DC interactions may occur in lymphoid organs as well as in nonlymphoid tissues, and their consequences are multiple. By inducing DC activation, NK-cell activation induced by tumor cells can indirectly promote antitumoral T-cell responses. Reciprocally, DCs activated through Toll-like receptors (TLRs) induce potent NK-cell activation in antiviral responses. Thus, DCs and NK cells are equipped with complementary sets of receptors that allow the recognition of various pathogenic agents, emphasizing the role of NK-cell/DC crosstalk in the coordination of innate and adaptive immune responses.

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