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Blood, 1 October 2005, Vol. 106, No. 7, pp. 2252-2258. Prepublished online as a Blood First Edition Paper on June 2, 2005; DOI 10.1182/blood-2005-03-1154. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-03-1154v1 106/7/2252    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Walzer, T. Articles by Vivier, E. Search for Related Content PubMed PubMed Citation Articles by Walzer, T. Articles by Vivier, E. Related Collections Immunobiology Review Articles Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES Natural-killer cells and dendritic cells: "l'union fait la force" Thierry Walzer, Marc Dalod, Scott H. Robbins, Laurence Zitvogel, and Eric Vivier From the Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique (INSERM-CNRS) Université Méditerranée, Campus de Luminy, Marseille, France; and Department of Clinical Biology, Equipe de recherche mixte 0208, INSERM, Institut Gustave Roussy, Villejuif, France. Several recent publications have focused on the newly described interactions between natural-killer (NK) cells and dendritic cells (DCs). Activated NK cells induce DC maturation either directly or in synergy with suboptimal levels of microbial signals. Immature DCs appear susceptible to autologous NK-cell-mediated cytolysis while mature DCs are protected. NK-cell-induced DC activation is dependent on both tumor necrosis factor- (TNF-)/interferon- (IFN-) secretion and a cell-cell contact involving NKp30. In vitro, interleukin-12 (IL-12)/IL-18, IL-15, and IFN-/ production by activated DCs enhance, in turn, NK-cell IFN- production, proliferation, and cytotoxic potential, respectively. In vivo, NK-cell/DC interactions may occur in lymphoid organs as well as in nonlymphoid tissues, and their consequences are multiple. By inducing DC activation, NK-cell activation induced by tumor cells can indirectly promote antitumoral T-cell responses. Reciprocally, DCs activated through Toll-like receptors (TLRs) induce potent NK-cell activation in antiviral responses. Thus, DCs and NK cells are equipped with complementary sets of receptors that allow the recognition of various pathogenic agents, emphasizing the role of NK-cell/DC crosstalk in the coordination of innate and adaptive immune responses. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Beuneu, J. Deguine, B. Breart, O. Mandelboim, J. P. Di Santo, and P. Bousso Dynamic behavior of NK cells during activation in lymph nodes Blood, October 8, 2009; 114(15): 3227 - 3234. [Abstract] [Full Text] [PDF] R. J. Prestwich, F. Errington, L. P. Steele, E. J. Ilett, R. S. M. Morgan, K. J. Harrington, H. S. Pandha, P. J. Selby, R. G. Vile, and A. A. Melcher Reciprocal Human Dendritic Cell-Natural Killer Cell Interactions Induce Antitumor Activity Following Tumor Cell Infection by Oncolytic Reovirus J. Immunol., October 1, 2009; 183(7): 4312 - 4321. [Abstract] [Full Text] [PDF] E. A. Haddad, L. K. Senger, and F. 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