|
|
Blood, 1 October 2005, Vol. 106, No. 7, pp. 2498-2505.
Prepublished online as a Blood First Edition Paper on June 16, 2005; DOI 10.1182/blood-2004-12-4840.
 Previous Article | Table of Contents | Next Article 
NEOPLASIA
Cooperating cancer-gene identification through oncogenic-retrovirus–induced insertional mutagenesis
Yang Du,
Sally E. Spence,
Nancy A. Jenkins, and
Neal G. Copeland
From the Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD.
Multiple cooperating mutations that deregulate different signaling pathways are required to induce cancer. Identifying these cooperating mutations is a prerequisite for developing better combinatorial therapies for treating cancer. Here we show that cooperating cancer mutations can be identified through oncogenic-retrovirus-induced insertional mutagenesis. Among 13 myeloid leukemias induced by transplanting into mice bone marrow cells infected in vitro with a replication-defective retrovirus carrying the Sox4 oncogene, 9 contained insertional mutations at known or suspected cancer genes. This likely occurred because rare bone marrow cells, in which the oncogenic retrovirus happened to integrate and in which it mutated a cooperating cancer gene, were selected because the host harbored a cooperating cancer mutation. Cooperativity between Sox4 and another gene, Mef2c, was subsequently confirmed in transplantation studies, in which deregulated Mef2c expression was shown to accelerate the myeloid leukemia induced by Sox4. Insertional mutagenesis of cooperating cancer genes by a defective oncogenic retrovirus provides a new method for identifying cooperating cancer genes and could aid in the development of better therapies for treating cancer. (Blood. 2005;106:2498-2505)
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Schwieger, A. Schuler, M. Forster, A. Engelmann, M. A. Arnold, R. Delwel, P. J. Valk, J. Lohler, R. K. Slany, E. N. Olson, et al.
Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C
Blood,
September 17, 2009;
114(12):
2476 - 2488.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. P Ryan
An alternative approach to medical genetics based on modern evolutionary biology. Part 1: mutation and symbiogenesis
J R Soc Med,
July 1, 2009;
102(7):
272 - 277.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Miyazaki, N. Yamasaki, H. Oda, T. Kuwata, Y. Kanno, M. Miyazaki, Y. Komeno, J. Kitaura, Z.-i. Honda, S. Warming, et al.
Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia
Blood,
May 7, 2009;
113(19):
4702 - 4710.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gekas, K. E. Rhodes, L. M. Gereige, H. Helgadottir, R. Ferrari, S. K. Kurdistani, E. Montecino-Rodriguez, R. Bassel-Duby, E. Olson, A. V. Krivtsov, et al.
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis
Blood,
April 9, 2009;
113(15):
3461 - 3471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. P. Medina, S. D. Castillo, S. Blanco, M. Sanz-Garcia, C. Largo, S. Alvarez, J. Yokota, A. Gonzalez-Neira, J. Benitez, H. C. Clevers, et al.
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer
Hum. Mol. Genet.,
April 1, 2009;
18(7):
1343 - 1352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bokhoven, S. L. Stephen, S. Knight, E. F. Gevers, I. C. Robinson, Y. Takeuchi, and M. K. Collins
Insertional Gene Activation by Lentiviral and Gammaretroviral Vectors
J. Virol.,
January 1, 2009;
83(1):
283 - 294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Khiem, J. G. Cyster, J. J. Schwarz, and B. L. Black
A p38 MAPK-MEF2C pathway regulates B-cell proliferation
PNAS,
November 4, 2008;
105(44):
17067 - 17072.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Schuler, M. Schwieger, A. Engelmann, K. Weber, S. Horn, U. Muller, M. A. Arnold, E. N. Olson, and C. Stocking
The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate
Blood,
May 1, 2008;
111(9):
4532 - 4541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. de Bont, J. M. Kros, M. M.C.J. Passier, R. E. Reddingius, P. A.E. S. Smitt, T. M. Luider, M. L. d. Boer, and R. Pieters
Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis
Neuro-oncol,
January 1, 2008;
10(5):
648 - 660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sinner, J. J. Kordich, J. R. Spence, R. Opoka, S. Rankin, S.-C. J. Lin, D. Jonatan, A. M. Zorn, and J. M. Wells
Sox17 and Sox4 Differentially Regulate {beta}-Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells
Mol. Cell. Biol.,
November 15, 2007;
27(22):
7802 - 7815.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. R. Ball, I. H. Pilz, M. Schmidt, S. Fessler, D. A. Williams, C. von Kalle, and H. Glimm
Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression
Blood,
September 15, 2007;
110(6):
1779 - 1787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. S. Kustikova, H. Geiger, Z. Li, M. H. Brugman, S. M. Chambers, C. A. Shaw, K. Pike-Overzet, D. d. Ridder, F. J. T. Staal, G. v. Keudell, et al.
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways
Blood,
March 1, 2007;
109(5):
1897 - 1907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Yuan, J. E. Payton, M. S. Holt, D. C. Link, M. A. Watson, J. F. DiPersio, and T. J. Ley
Commonly dysregulated genes in murine APL cells
Blood,
February 1, 2007;
109(3):
961 - 970.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Brown, C. R. Wilkinson, S. R. Waterman, C. H. Kok, D. G. Salerno, S. M. Diakiw, B. Reynolds, H. S. Scott, A. Tsykin, G. F. Glonek, et al.
Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modeling
J. Leukoc. Biol.,
August 1, 2006;
80(2):
433 - 447.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Takeda, C. Goolsby, and N. R. Yaseen
NUP98-HOXA9 Induces Long-term Proliferation and Blocks Differentiation of Primary Human CD34+ Hematopoietic Cells.
Cancer Res.,
July 1, 2006;
66(13):
6628 - 6637.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Seggewiss, S. Pittaluga, R. L. Adler, F. J. Guenaga, C. Ferguson, I. H. Pilz, B. Ryu, B. P. Sorrentino, W. S. Young III, R. E. Donahue, et al.
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque
Blood,
May 15, 2006;
107(10):
3865 - 3867.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
