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Blood, 1 October 2005, Vol. 106, No. 7, pp. 2543-2550.
Prepublished online as a Blood First Edition Paper on June 14, 2005; DOI 10.1182/blood-2005-03-1239.
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PHAGOCYTES
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
David M. Underhill,
Eddie Rossnagle,
Clifford A. Lowell, and
Randi M. Simmons
From the Institute for Systems Biology, Seattle, WA; and Department of Laboratory Medicine, University of California, San Francisco.
Dectin-1 is a lectin receptor for  -glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory cytokines. The mechanisms by which Dectin-1 mediates intracellular signaling are just beginning to be defined. Spleen tyrosine kinase (Syk) is a protein tyrosine kinase that is critical for adaptive immune responses where it mediates signaling through B-cell receptors, T-cell receptors, and Fc receptors. Here we report that Dectin-1 activates Syk in macrophages and is important for Dectin-1-stimulated reactive oxygen production, but not for phagocytosis. Syk activation is restricted to a subpopulation of macrophages that is in equilibrium with cells that cannot activate the pathway. The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential. (Blood. 2005;106:2543-2550)
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|
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|
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|
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