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Blood, 1 October 2005, Vol. 106, No. 7, pp. 2543-2550. Prepublished online as a Blood First Edition Paper on June 14, 2005; DOI 10.1182/blood-2005-03-1239. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-03-1239v1 106/7/2543    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Underhill, D. M. Articles by Simmons, R. M. Search for Related Content PubMed PubMed Citation Articles by Underhill, D. M. Articles by Simmons, R. M. Related Collections Phagocytes Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PHAGOCYTES Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production David M. Underhill, Eddie Rossnagle, Clifford A. Lowell, and Randi M. Simmons From the Institute for Systems Biology, Seattle, WA; and Department of Laboratory Medicine, University of California, San Francisco. Dectin-1 is a lectin receptor for -glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory cytokines. The mechanisms by which Dectin-1 mediates intracellular signaling are just beginning to be defined. Spleen tyrosine kinase (Syk) is a protein tyrosine kinase that is critical for adaptive immune responses where it mediates signaling through B-cell receptors, T-cell receptors, and Fc receptors. Here we report that Dectin-1 activates Syk in macrophages and is important for Dectin-1-stimulated reactive oxygen production, but not for phagocytosis. Syk activation is restricted to a subpopulation of macrophages that is in equilibrium with cells that cannot activate the pathway. The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential. (Blood. 2005;106:2543-2550) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. J. Robinson, F. Osorio, M. Rosas, R. P. Freitas, E. Schweighoffer, O. Gross, J. S. Verbeek, J. Ruland, V. Tybulewicz, G. D. Brown, et al. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection J. Exp. Med., August 31, 2009; 206(9): 2037 - 2051. [Abstract] [Full Text] [PDF] S. Xu, J. Huo, M. 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